4463-42-7Relevant articles and documents
A General C(sp3)-C(sp3) Cross-Coupling of Benzyl Sulfonylhydrazones with Alkyl Boronic Acids
Merchant, Rohan R.,Lopez, Jovan A.
supporting information, p. 2271 - 2275 (2020/03/13)
A general transition-metal-free cross-coupling between benzylic sulfonylhydrazones and 1°, 2°, or 3° alkyl boronic acids is reported. The base-promoted reaction is operationally simple and exhibits a broad substrate scope to forge a variety of alkyl-alkyl bonds, including between sterically encumbered secondary and tertiary sp3-carbons. The ability of this method to simplify retrosynthetic analysis is exemplified by the improved synthesis of multiple medicinally relevant scaffolds.
New statine intermediate, and using the same pitavastatin, rosuvastatin, and method of manufacturing cerivastatin [...]
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Paragraph 0107-0109, (2016/10/08)
The present invention provides a novel statin intermediate represented by chemical formula 1, and a method for producing pitavastatin, rosuvastatin, cerivastatin and fluvastatin by using the intermediate. (In chemical formula 1: n = 1, 2 or 3; Ar = a phenyl group or a phenyl group substituted with a C1-C4 alkyl or C6-C10 aryl, a naphthyl group or a naphthyl group substituted with a C1-C4 alkyl or C6-C10 aryl, or an anthracene group or an anthracene group substituted with a C1-C4 alkyl or C6-C10 aryl; and R1 is a C1-C8 alkyl, secondary alkyl, tertiary alkyl, aryl or aralkyl.)
Observations on the deprotection of pinanediol and pinacol boronate esters via fluorinated intermediates
Inglis, Steven R.,Woon, Esther C. Y.,Thompson, Amber L.,Schofield, Christopher J.
supporting information; experimental part, p. 468 - 471 (2010/03/25)
(Chemical Equation Presented) Methods for the deprotection of pinanediol and pinacol esters of various boronic acids via fluoroborane intermediates were evaluated. Treatment of the boronate esters with potassium hydrogen difluoride normally gives trifluor
