4464-75-9

Basic information

• Product Name: 1,2-Bis(3-methoxy-4-hydroxyphenyl)-1,2-ethanediol
• Synonyms: 1,2-Bis(3-methoxy-4-hydroxyphenyl)-1,2-ethanediol;1,2-Bis(4-hydroxy-3-methoxyphenyl)-1,2-ethanediol;4,4'-(1,2-Dihydroxyethane-1,2-diyl)bis(2-methoxyphenol);Hydrovanilloin
• CAS NO: 4464-75-9
• Molecular Formula: C₁₆H₁₈O₆
• Molecular Weight: 306.3105
• Mol File: 4464-75-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 532.2°Cat760mmHg
• Flash Point: 275.7°C
• Appearance: /
• Density: 1.365g/cm³
• Vapor Pressure: 3.72E-12mmHg at 25°C
• Refractive Index: 1.636
• CAS DataBase Reference: 1,2-Bis(3-methoxy-4-hydroxyphenyl)-1,2-ethanediol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Bis(3-methoxy-4-hydroxyphenyl)-1,2-ethanediol(4464-75-9)
• EPA Substance Registry System: 1,2-Bis(3-methoxy-4-hydroxyphenyl)-1,2-ethanediol(4464-75-9)

Safety Data

• Hazardous Substances Data: 4464-75-9(Hazardous Substances Data)

Usage

General Description

1,2-Bis(3-methoxy-4-hydroxyphenyl)-1,2-ethanediol, also known as bisguaiacol F or bisguaiacol Fumarate, is a chemical compound with antioxidant properties. It is commonly used in the cosmetic and pharmaceutical industry for its ability to protect against oxidative stress and free radical damage. The compound is a derivative of guaiacol, a natural phenolic compound found in various plants, and is known for its anti-inflammatory and anti-cancer properties. 1,2-Bis(3-methoxy-4-hydroxyphenyl)-1,2-ethanediol has also been studied for its potential neuroprotective effects and has shown promise in the treatment of neurological disorders.

InChI:InChI=1/C16H18O6/c1-21-13-7-9(3-5-11(13)17)15(19)16(20)10-4-6-12(18)14(8-10)22-2/h3-8,15-20H,1-2H3

Upstream product

• 64-17-5 ethanol 
• 121-33-5 vanillin 
• 7732-18-5 water 
• 5463-22-9 vanillil 
• 69887-33-8 1,1'-bis(3-methoxy-4-benzyloxy)-(E)-stilbene 
• 7329-69-3 (E)-3,3'-dimethoxy-4,4'-dihydroxystilbene 
• 5932-68-3 (E)-2-methoxy-4-(1-propenyl)phenol 
• 100-52-7 benzaldehyde 

Downstream Products

• 5463-22-9 vanillil 
• 7329-69-3 (E)-3,3'-dimethoxy-4,4'-dihydroxystilbene 
• 40060-11-5 1,2-Bis-(3-formyl-4,5-dimethoxy-phenyl)-ethan 
• 40060-10-4 1,2-Bis-(3-formyl-4-hydroxy-5-methoxy-phenyl)-ethan 
• 40060-12-6 1,2-Bis-(4-acetoxy-3-allyl-5-methoxyphenyl)-ethan 
• 40218-59-5 1,2-Bis-(3-allyl-4,5-dimethoxyphenyl)-ethan 
• 40060-09-1 1,2-bis(4-(allyloxy)-3-methoxyphenyl)ethane 
• 40060-14-8 1,2-Bis-(3,4-dimethoxy-5-(1-propenyl)-phenyl)-ethan 
• 40060-13-7 1,2-Bis-(3-allyl-4-hydroxy-5-methoxyphenyl)-ethan 
• 18256-53-6 4,4’-dihydroxy-3,3’-dimethoxybibenzyl 

Relevant articles and documents

Selectivity Control in Photocatalytic Valorization of Biomass-Derived Platform Compounds by Surface Engineering of Titanium Oxide

-

Renewable thermosetting resins and thermoplastics from vanillin

Two cyanate ester resins and a polycarbonate thermoplastic have been synthesized from vanillin. The bisphenol precursors were prepared by both an electrochemical route as well as by a McMurry coupling reaction. 1,2-Bis(4-cyanato-3-methoxyphenyl)ethene (6) had a high melting point of 237 °C and did not cure completely under a standard cure protocol. In contrast, the reduced version, 1,2-bis(4-cyanato-3-methoxyphenyl)ethane (7) melted at 190 °C and underwent complete cure to form a thermoset material with Tg = 202 °C. 7 showed thermal stability up to 335 °C and decomposed via formation of phenolics and isocyanic acid. A polycarbonate was then synthesized from the reduced bisphenol by a transesterification reaction with diphenylcarbonate. The polymer had Mn = 3588, Mw/Mn = 1.9, and a Tg of 86 °C. TGA/FTIR data suggested that the polycarbonate decomposed via formation of benzodioxolones with concomitant elimination of methane. The results show that vanillin is a useful precursor to both thermosetting resins and thermoplastics without significant modification. This journal is

A convenient synthesis of unsymmetrical pinacols by coupling of structurally similar aromatic aldehydes mediated by low-valent titanium

The one-pot, selective cross pinacol-type couplings between two structurally similar aromatic aldehydes promoted by low-valent titanium generated unsymmetrical pinacols in moderate to good isolated yields in an erythrolthreo ratio of up to 91:9. This synt