4481-28-1

Basic information

• Product Name: 3-CARBOXAMIDOBENZOIC ACID
• Synonyms: 3-CARBOXAMIDOBENZOIC ACID;3-ForMaMidobenzoic acid;Benzoic acid, 3-(aMinocarbonyl)-;3-carboxybenzaMide;3-carbaMoylbenzoic acid
• CAS NO: 4481-28-1
• Molecular Formula: C₈H₇NO₃
• Molecular Weight: 165.15
• Mol File: 4481-28-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 394.2°C at 760 mmHg
• Flash Point: 192.2°C
• Appearance: /
• Density: 1.368g/cm³
• Vapor Pressure: 6.38E-07mmHg at 25°C
• Refractive Index: 1.615
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Aqueous Base (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated)
• Stability: Hygroscopic
• CAS DataBase Reference: 3-CARBOXAMIDOBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CARBOXAMIDOBENZOIC ACID(4481-28-1)
• EPA Substance Registry System: 3-CARBOXAMIDOBENZOIC ACID(4481-28-1)

Safety Data

• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 4481-28-1(Hazardous Substances Data)

Usage

General Description

3-Carboxamidobenzoic acid, also known as N-(3-Carboxyphenyl)acetamide, is a chemical compound with the molecular formula C9H8N2O4. It is a white to off-white crystalline powder that is soluble in water and commonly used in the pharmaceutical and chemical industries. 3-Carboxamidobenzoic acid is a derivative of benzoic acid and is used as a building block in the synthesis of various pharmaceutical drugs and organic compounds. It has applications in the production of anti-inflammatory and analgesic drugs, as well as in the synthesis of dyes and pigments. This chemical compound undergoes various chemical reactions and can participate in amide and carboxylic acid reactions, making it a versatile building block for the synthesis of various organic compounds.

InChI:InChI=1/C8H7NO3/c9-7(10)5-2-1-3-6(4-5)8(11)12/h1-4H,(H2,9,10)(H,11,12)

Upstream product

• 7446-70-0 aluminium trichloride 
• 55-21-0 benzamide 
• 925159-45-1 C₁₆H₁₅NO₃ 
• 10388-19-9 m-iodobenzamide 
• 1877-71-0 benzene 1,3-dicarboxylic acid monomethyl ester 
• 1459-93-4 dimethyl Isophthalate 
• 106748-24-7 methyl 3-carbamoylbenzoate 
• 618-47-3 m-toluamide 
• 75-44-5 phosgene 
• 3441-03-0 3-(methoxycarbonyl)benzoyl chloride 

Downstream Products

• 1111556-37-6 N-(1-propyl-1H-benzo[d]imidazol-2-yl)isophthalamide 
• 1337544-62-3 4-amino-5-((2-β-carbamoylbenzamido)-2-methylpropoxy)-2-methylquinoline-3-carboxylic acid 
• 1337544-65-6 ethyl 4-amino-5-((2-β-carbamoylbenzamido)-2-methylpropoxy)-2-methylquinoline-3-carboxylate 
• 1259931-90-2 C₄₁H₄₂F₂N₆O₃ 
• 773056-98-7 3-(5-cyclohexylamino-[1,3,4]thiadiazol-2-yl)-benzamide 

Relevant articles and documents

Design and synthesis of 3-aminophthalazine derivatives and structural analogues as PDE5 inhibitors: anti-allodynic effect against neuropathic pain in a mouse model

Neuropathic pain is a chronic pain caused by a lesion or disease affecting the somatosensory nervous system. To date, no specific treatment has been developed to cure this pain. Antidepressants and anticonvulsant drugs are used, but they do not demonstrate universal efficacy, and they often cause detrimental adverse effects. Some studies highlighted the efficacy of sildenafil, a well-known inhibitor of phosphodiesterase 5 (PDE5, (IC50 = 3.3 nM)), in models of pain. Based on these results, we focused our attention on MY 5445, another known PDE5 inhibitor. Homologues, isosteres and structural analogues of MY 5445 were designed and all synthesized compounds were evaluated for their inhibitory activity toward PDE5. Selectivity profiles towards other PDE1-4 isoenzymes, water solubility and stability in acidic medium of the most potent PDE5 inhibitors were determined and the aminophthalazine 16h and its mimetic 41n (3-aminoindazole)were evaluated in comparison to MY 5445 (4b)in vivo in a model of neuropathic pain induced by sciatic nerve cuffing in mice (3 and 0.5 mg/kg, ip twice a day). Both compounds showed the same efficacy on neuropathic allodynia as MY 5445, and thus produced a significant relief of mechanical hypersensitivity after 12 days of treatment.

Diaminopropionic acid derivatives

A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.