45127-11-5

Basic information

• Product Name: Coenzyme
• Synonyms: 2,2'-dithiodiethanesulfonic acid;16208-51-8 (Di-hydrochloride salt);2,2'-Dithidi-1-ethanesulfonic acid;Bis(2-sulfoethyl)disulfide;Ethanesulfonic acid, 2,2'-dithiobis-;Omega,omega'-ethanedisulfidedisulfonic acid;2-[(2-sulfoethyl)disulfanyl]ethane-1-sulfonic acid;2,2'-disulfanediyldiethanesulfonic acid
• CAS NO: 45127-11-5
• Molecular Formula: C4H10O6S4
• Molecular Weight: 282.38
• Mol File: 45127-11-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.769±0.06 g/cm3 (20 ºC 760 Torr)
• Refractive Index: 1.637
• CAS DataBase Reference: Coenzyme(CAS DataBase Reference)
• NIST Chemistry Reference: Coenzyme(45127-11-5)
• EPA Substance Registry System: Coenzyme(45127-11-5)

Safety Data

• Hazardous Substances Data: 45127-11-5(Hazardous Substances Data)

Usage

Uses

Coenzyme M can be used for F430 Biosynthesis and insertion.

InChI:InChI=1/C4H10O6S4/c5-13(6,7)3-1-11-12-2-4-14(8,9)10/h1-4H2,(H,5,6,7)(H,8,9,10)

Upstream product

• 3375-50-6 2-Mercaptoethanesulfonic acid 
• 4263-52-9 sodium 2-bromethanesulfonate 
• 98022-97-0 2,2'-dithiobisethanesulfonyl chloride 
• 19767-45-4 mesna 

Relevant articles and documents

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Reducing toxic effects of carboplatin using dithioethers

To reduce the toxic effect of carboplatin, particularly myelosuppression and emesis, a dithioether having the formula R1 -(CH2)n --S--S--(CH2)m --R2 (I) wherein: PA1 each of R1 and R2 individually is SO3 H or PO3 H2 ; and PA1 each of m and n is individually 1, 2, 3 or 4; PAL or a pharmaceutically acceptable salt thereof, preferably disodium 2,2'-dithiobis(ethane sulfonate) (dimesna), is administered in combination with carboplatin to a patient, at substantially the same time or sequentially, whereby the dithioether and the carboplatin become co-present in the blood of the patient. Compositions comprising carboplatin and the dithioether are included in the invention.