45789-64-8Relevant articles and documents
High yield synthesis of d-phenylglycine and its derivatives by nitrilase mediated dynamic kinetic resolution in aqueous-1-octanol biphasic system
Qiu, Jian,Su, Erzheng,Wang, Wei,Wei, Dongzhi
, p. 1448 - 1451 (2014)
A strategy of nitrilase mediated dynamic kinetic resolution toward the synthesis of d-phenylglycine was developed, using aqueous-1-octanol biphasic system. Due to the efficient suppression of the decomposition of phenylglycinonitrile, a maximum yield of 81% is obtained. This result indicates that the nitrilase mediated dynamic kinetic resolution is a promising method toward the synthesis of d-phenylglycine and its derivatives.
MANUFACTURING METHOD OF OPTICALLY ACTIVE AMINONITRILE COMPOUND AND MANUFACTURING METHOD OF OPTICALLY ACTIVE AMINO ACID
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Paragraph 0010; 0025-0026, (2017/12/27)
PROBLEM TO BE SOLVED: To provide a method for manufacturing an optically active aminonitrile compound with high purity suitable for manufacturing optically active amino acid and a method for manufacturing an optically active amino acid. SOLUTION: An optically active imine compound is obtained by condensing an optically active primary amine compound and a carbonyl compound in a solvent, a crystal of an optically active aminonitrile compound is deposited by adding hydrogen cyanide or a salt thereof to the imine compound in a solvent and asymmetric amplification for extremely enhancing diastereomer ratio thereof is conducted. The resulting aminonitrile compound with high optical purity is converted to optically active amino acid by known acid hydrolysis without deteriorating optical purity. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2017,JPOandINPIT
A CONVENIENT METHOD FOR OPTICAL RESOLUTIONS VIA DIASTEREOISOMERIC SALT FORMATION
Acs, M.,Fogassy, E.,Faigl, F.
, p. 2465 - 2470 (2007/10/02)
With the advantage of the method using two immiscible solvents and half-equivalent amount of the resolving agent, higher optical purity can be obtained than in cases of any other resolution via diastereoisomeric salt formation, besides it is a faster procedure for resolution of a new racemate as well.