46006-36-4

Basic information

• Product Name: 1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID
• Synonyms: Benzimidazole-4-carboxylicacid;1H-Benzimidazole-4-carboxylic acid 97%;1H-Benzimidazole-4-carboxylicacid(9CI);4-Benzimidazolecarboxylic acid;4-Carboxy-1H-benzimidazole;1H-benzo[d]iMidazole-7-carboxylic acid;1H-1,3-benzodiazole-4-carboxylic acid;1H-benzo[d]imidazol-7-carboxylic acid
• CAS NO: 46006-36-4
• Molecular Formula: C₈H₆N₂O₂
• Molecular Weight: 162.15
• Product Categories: BENZIMIDAZOLE;pharmacetical;Carboxylic Acids;Imidazoles & Benzimidazoles;Carboxylic Acids;Imidazoles & Benzimidazoles;Benzoimidazole;Building Blocks
• Mol File: 46006-36-4.mol
• Article Data: 12

Chemical Properties

• Melting Point: >300 °C
• Boiling Point: 542.472 °C at 760 mmHg
• Flash Point: 281.877 °C
• Appearance: /
• Density: 1.507 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.743
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 0.17±0.10(Predicted)
• CAS DataBase Reference: 1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID(46006-36-4)
• EPA Substance Registry System: 1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID(46006-36-4)

Safety Data

• Hazard Codes: Xi,N
• Statements: 36-51
• Safety Statements: 53-26-61
• RIDADR: UN 3077 9 / PGIII
• HazardClass: IRRITANT
• Hazardous Substances Data: 46006-36-4(Hazardous Substances Data)

Usage

General Description

1H-Benzoimidazole-4-carboxylic acid is a chemical compound with the molecular formula C8H6N2O2. It is an aromatic heterocyclic compound consisting of a benzene ring fused to an imidazole ring, with a carboxylic acid functional group attached at position 4. 1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID has potential applications in the pharmaceutical industry, specifically in the development of new drugs due to its structural properties and ability to interact with biological systems. Additionally, 1H-Benzoimidazole-4-carboxylic acid has been studied for its potential anti-inflammatory and antimicrobial properties, making it an interesting compound for further research and development.

InChI:InChI=1/C8H6N2O2/c11-8(12)5-2-1-3-6-7(5)10-4-9-6/h1-4H,(H,9,10)(H,11,12)

Upstream product

• 64-18-6 formic acid 
• 603-81-6 2,3-diaminobenzoic acid 
• 606-18-8 3-nitroanthranilic acid 
• 77326-45-5 2-carbamoyl-3-nitrobenzoic acid 
• 116465-92-0 3-Amino-2-nitrobenzoic acid 
• 122-51-0 orthoformic acid triethyl ester 
• 641-70-3 3-nitrophthalic acid anhydride 

Downstream Products

• 51-17-2 benzoimidazole 
• 390406-77-6 1H-benzoimidazole-4-carboxylic acid (4-{3-[2-(3,4-dichloro-phenyl)-2-hydroxy-ethyl]-3-isopropyl-ureido}-phenyl)-amide 
• 65658-13-1 (1H-benzo[d]imidazol-4-yl)methanol 
• 144876-36-8 1H-benzo[d]imidazole-4-carbaldehyde 
• 37619-25-3 methyl 1H-benzo[d]imidazole-4-carboxylate 
• 672957-91-4 methyl 1-methyl-1H-benzo[d]imidazole-4-carboxylate 
• 1610736-94-1 N-((1s,4s)-4-(2-(2'-((dimethylamino)methyl)-4'-hydroxybiphenyl-3-yloxy)-5-fluoronicotinamido)cyclohexyl)-1H-benzo[d]imidazole-4-carboxamide trifluoroacetic acid salt 
• 1427422-50-1 1-(5-chloro-2-((4-chloro-2-fluorobenzyl)oxy)benzyl)-1H-benzo[d]imidazole-4-carboxylic acid 

Relevant articles and documents

MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS

The present invention relates to compounds of formula (I), or their isotopic forms, stereoisomers, tautomers or pharmaceutically acceptable salt (s) thereof as muscarinic M1 receptor positive allosteric modulators (M1 PAMs). The present invention describes the preparation, pharmaceutical composition and the use of compound formula (I).

OXADIAZOLE DERIVATIVES AND PHARMACEUTICAL USES THEREOF

PROBLEM TO BE SOLVED: To provide therapeutic or preventive agents for various diseases or symptoms associated with a serotonin 4 receptor (particularly, neuropsychiatric diseases such as Alzheimer-type dementia). SOLUTION: The present invention provides a compound represented by formula (1) or a pharmaceutically acceptable salt thereof. In the formula (1), Het represents formula (Het-1) or the like, A represents formula (A-1) or the like, B represents (B-1) or the like, R1A represents a hydrogen atom, an alkyl group or the like, R2A, R5, R6 and R7 represent a hydrogen atom, a halogen atom, an alkyl group or the like, R8 and R9 represent a hydrogen atom, an alkyl group or the like, and l represents an integer of 0-4. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT

A facile one-pot synthesis of benzimidazoles from 2-nitroanilines by reductive cyclization

A facile one-pot process to prepare benzimidazole derivatives is described. Reductive cyclization of a serial of 2-nitroanilines with orthoesters in the presence of Pd/C in methanol at room temperature, which is promoted by a catalytic amount of acetic acid, affords the corresponding benzimidazole derivatives in high yields.