461-05-2Relevant articles and documents
Practical and efficient utilisation of (R)-3-chloro-1,2-propanediol in synthesis of L-carnitine
Yang, Yunxu,Wang, Weili,Wumaier, Aikeremu,Sheng, Ruilong,Zhang, Xuetao,Zhang, Tianyi
scheme or table, p. 371 - 372 (2011/10/09)
As a by-product originating from Salen Co(III) catalysed hydrolytic kinetic resolution (HKR) of (±)-epichlorohydrin in the manufacturing procedure of L-Carnitine, (R)-3-chloro-1,2-propanediol was utilised as a starting chiral material to prepare via key nitrile intermediates and by a final hydrolysis L-Carnitine. The new synthetic approach demonstrated an efficient utilisation of the by-product.
PROCESS FOR PRODUCING CARNITINAMIDE
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Page/Page column 7-8; 11; 1/1, (2008/06/13)
[PROBLEMS] To provide a process in which in the production of carnitinamide as a production intermediate for L-carnitine, carnitine nitrile can be hydrated into carnitinamide with high selectivity so that high-purity carnitinamide excelling as a substrate for optical resolution or microbial stereoselective hydrolysis can be produced in high yield. [MEANS FOR SOLVING PROBLEMS] There is provided a process comprising hydrating carnitine nitrile into carnitinamide with the use of a catalyst containing manganese oxide to thereby realize production of carnitinamide containing substantially none of carnitine by-products in high yield. As a result, carnitinamide of extremely high purity can be produced through simple and easy crystallization operation.
An efficient synthesis of (R)-carnitine
Kasai,Sakaguchi
, p. 1211 - 1212 (2007/10/02)
An efficient synthesis of (R)-carnitine hydrochloride is described. The starting material is obtained by microbial resolution of (RS)-2,3-dichloro-1-propanol.
