466-99-9 Usage
Description
Hydromorphone (Item No. 15463) is an analytical reference material categorized as an opioid. It is a metabolite of morphine (Item Nos. 15464 | ISO60147). Like other opioid analgesics, hydromorphone is commonly abused. Hydromorphone is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.
Uses
Different sources of media describe the Uses of 466-99-9 differently. You can refer to the following data:
1. Hydromorphone, a potent opioid, is used mainly in the palliative care seing
or in patients who are not opioid naive. It can be useful if considering opioid
rotation. Hydromorphone 1.3mg is approximately equianalgesic to morphine
10 mg. Both immediate- and sustained-release preparations are available.
2. Meperidine (pethidine) is available as parenteral and oral preparations.
There is no evidence that this opioid provides any advantage over morphine,
such as treatment of colicky-type pain. Its analgesic action is fairly short, but
the metabolite normeperidine can accumulate (t1/2 ~ 15h) if repeated doses
are given and especially if there is renal dysfunction. Normeperidine is a
CNS stimulant and can cause seizures. Its clearance is significantly reduced
in hepatic disease. Chronic use may result in enzyme induction and an
increase in normeperidine plasma concentrations. Its metabolism is
decreased by the oral contraceptive pill.
Meperidine has other significant effects related to activity at non-opioid
receptors. For example, its atropine-like action may cause a tachycardia, in
addition to direct myocardial depression at high doses. It was used originally
as a bronchodilator. It can also reduce shivering related to hypothermia or
epidural anaesthesia, although the mechanism for this is not fully
understood. Meperidine also has a local anaesthetic-like membrane
stabilising action.
Definition
ChEBI: A morphinane alkaloid that is a hydrogenated ketone derivative of morphine. A semi-synthetic drug, it is a centrally acting pain medication of the opioid class.
Biological Functions
Hydromorphone is eight times as potent as morphine
but has less bioavailability following oral administration.
Its side effects do not differ from those of morphine
but are more intense. Hydromorphone is
indicated for use in severe pain and in high doses for relief
of pain in opioid-addicted patients.
General Description
Hydromorphone, (Dilaudid) is a synthetic derivative ofmorphine prepared by the catalytic hydrogenation and dehydrogenationof morphine under acidic conditions, using alarge excess of platinum or palladium. Oxidation of the 6-OH of morphine resulted in a compound with decreased potency.Reducing the 7,8 double bond of morphine increasedthe flexibility of the molecule and resulted in a compoundwith slightly enhanced binding. Making both of these structuralchanges to morphine-produced hydromorphone, acompound approximately 5 times as potent as morphine.Hydromorphone was introduced in 1926 and is available as animmediate release tablet, a liquid, and a suppository. A sustainedrelease form is available in some countries but not inthe United States. The sustained release form was removedfrom the U.S. market in 2005 when studies showed that drinking8 oz of alcohol (40%) could cause the drug to be releasedfrom the capsule immediately and lead to concentrations thatwere 5.5 times higher than in patients that did not drink alcohol.This potentially lethal combination prompted the Foodand Drug Administration (FDA) to remove it from the market.
Check Digit Verification of cas no
The CAS Registry Mumber 466-99-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,6 and 6 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 466-99:
(5*4)+(4*6)+(3*6)+(2*9)+(1*9)=89
89 % 10 = 9
So 466-99-9 is a valid CAS Registry Number.
InChI:InChI=1/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,16,19H,3,5-8H2,1H3/t10-,11+,16-,17-/m0/s1
466-99-9Relevant articles and documents
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Weiss,Weiner
, p. 194,195 (1949)
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Method for synthesizing hydromorphone
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Paragraph 0041; 0042; 0043; 0047; 0048; 0049; 0050; 0054, (2018/07/07)
The invention discloses a method for synthesizing hydromorphone by using a continuous flow microchannel reactor. According to the method, by the temperature and the reaction speed of each module of the continuous flow microchannel reactor are controlled, a quenching is integrated into the continuous flow microchannel reactor, and by control of optimal reaction state of hydromorphone synthesis rawmaterials and a catalyst and the reaction speed, the reaction speed is improved. At the same time, through addition of the quenching module, the reaction can be promptly quenched, the precise controlof the reaction time can be achieved, over oxidation in a key step of Oppenauer Oxidation during hydromorphone synthesis can be reduced, production of by-products can be reduced, and reaction yield and hydromorphone product purity can be improved.
NEW PROCESS FOR PREPARING HYDROMORPHONE AND DERIVATIVES THEREOF
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Page/Page column 22; 23; 24; 25; 26; 27; 28; 29; 30, (2017/02/24)
There is provided a novel process for the preparation of a compound of formula (I), wherein R1 is as described in the description, by demethylation of a corresponding O-methyl derivative.
This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.