4703-32-6

Basic information

• Product Name: L-Tyrosine, N-[(4-methylphenyl)sulfonyl]-
• CAS NO: 4703-32-6
• Molecular Formula: C16H17NO5S
• Molecular Weight: 335.381
• Mol File: 4703-32-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: L-Tyrosine, N-[(4-methylphenyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Tyrosine, N-[(4-methylphenyl)sulfonyl]-(4703-32-6)
• EPA Substance Registry System: L-Tyrosine, N-[(4-methylphenyl)sulfonyl]-(4703-32-6)

Safety Data

• Hazardous Substances Data: 4703-32-6(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 4089-07-0 L-tyrosine ethyl ester monohydrochloride 
• 60-18-4 L-tyrosine 
• 13504-90-0 (S)-2-((4-methylphenyl)sulfonamido)-3-(4-(tosyloxy)phenyl)propanoic acid 
• 58559-09-4 Ethyl N-(p-tosyl)tyrosinate 
• 101585-61-9 N-tosyl L-tyrosine methyl ester 

Downstream Products

• 101719-83-9 3,5-bis-hydroxymethyl-N-(toluene-4-sulfonyl)-tyrosine 
• 122702-30-1 (2S,3S)-2-[(S)-2-(Benzyloxycarbonyl-methyl-amino)-3-(4-benzyloxycarbonyloxy-phenyl)-propionylamino]-3-methyl-pentanoic acid methyl ester 
• 122389-32-6 (S)-2-(Benzyloxycarbonyl-methyl-amino)-3-(4-benzyloxycarbonyloxy-phenyl)-propionic acid 4-nitro-phenyl ester 
• 91650-46-3 (S)-2-(Benzyloxycarbonyl-methyl-amino)-3-(4-benzyloxycarbonyloxy-phenyl)-propionic acid 
• 109369-51-9 (S)-2-Methylamino-3-[4-(toluene-4-sulfonyloxy)-phenyl]-propionic acid 
• 110055-30-6 (S)-3-(4-Hydroxy-phenyl)-2-methylamino-propionic acid tert-butyl ester 
• 537-49-5 N-methyl-L-tyrosine 
• 94917-43-8 (R)-3-Carboxymethylsulfanyl-2-[(S)-3-(4-hydroxy-phenyl)-2-(toluene-4-sulfonylamino)-propionylamino]-propionic acid 
• 94680-08-7 (R)-2-[(S)-3-(4-Hydroxy-phenyl)-2-(toluene-4-sulfonylamino)-propionylamino]-3-methylsulfanyl-propionic acid 
• 96070-56-3 (R)-3-Benzylsulfanyl-2-[(S)-3-(4-hydroxy-phenyl)-2-(toluene-4-sulfonylamino)-propionylamino]-propionic acid 
• 95281-81-5 (S)-2-[(S)-3-(4-Hydroxy-phenyl)-2-(toluene-4-sulfonylamino)-propionylamino]-4-methylsulfanyl-butyric acid 
• 101728-84-1 3,5-bis-chloromethyl-N-(toluene-4-sulfonyl)-tyrosine 
• 292157-42-7 2-[6-(4-{(S)-2-[[(E)-5-(tert-Butyl-diphenyl-silanyloxy)-pent-3-enyl]-(toluene-4-sulfonyl)-amino]-2-methoxycarbonyl-ethyl}-phenoxy)-hexyl]-malonic acid dimethyl ester 
• 292157-36-9 (S)-2-[[(E)-5-(tert-Butyl-diphenyl-silanyloxy)-pent-3-enyl]-(toluene-4-sulfonyl)-amino]-3-{4-[6-(tetrahydro-pyran-2-yloxy)-hexyloxy]-phenyl}-propionic acid methyl ester 

Relevant articles and documents

Development of amino acid conjugated sulfonamides as potent antiulcer agent

A series of 2-{[(4-methylphenyl) sulfonyl] amino}-3-sulfanylpropanoic acid (1a) and its analogs 1b-j have been synthesized. These compounds were screened for their in vivo efficacy in pyloric ligation model. Compounds 1a and 1b with higher antiulcer potential were further screened in other gastric models to explore the mode of antiulcer action. To further understand the mode of action, in vitro inhibition of H+/K+ ATPase activity in gastric microsome isolated from rat stomach was studied. This was rationalized by in silico experiments.

HIV protease inhibitors based on amino acid derivatives

A compound selected from the group consisting of a compound of formula I 1a compound of formula II 2and when the compound of formula I and II comprises an amino group pharmaceutically acceptable ammonium salts thereof, wherein R1, R2, Cx, n, R3, R4, R5, Y are as defined in the specification.

Total synthesis of tricyclic azaspirane derivatives of tyrosine: FR901483 and TAN1251C

A solution to the long-standing problem presented by the oxidative cyclization of a phenolic 3-arylpropionamide to a spirolactam has been developed in this laboratory via oxazoline chemistry. This research was motivated by our interest in some novel tricyclic azaspirane natural products formally derived from tyrosine, such as FR901483 and TAN1251C. In this paper, we disclose full details of the total synthesis of these substances.