4714-67-4

Basic information

• Product Name: 4-AMINOTHIOBENZAMIDE
• Synonyms: 4-amino-benzenecarbothioamid;4-aminobenzenecarbothioamide;p-aminobenzothiamide;p-aminothio-benzamid;4-AMINOTHIOBENZAMIDE;4-Amino Thiobenzamide p-Amino Thiobenzamide;PARA-AMINOTHIOBENZAMIDE;p-AminoThioBenzamide
• CAS NO: 4714-67-4
• Molecular Formula: C₇H₈N₂S
• Molecular Weight: 152.22
• Product Categories: Amines
• Mol File: 4714-67-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 182 ºC
• Boiling Point: 325.6°Cat760mmHg
• Flash Point: 150.7°C
• Appearance: /
• Density: 1.286
• Vapor Pressure: 0.000227mmHg at 25°C
• Refractive Index: 1.719
• PKA: 13.25±0.29(Predicted)
• CAS DataBase Reference: 4-AMINOTHIOBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINOTHIOBENZAMIDE(4714-67-4)
• EPA Substance Registry System: 4-AMINOTHIOBENZAMIDE(4714-67-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-43-36-22
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 4714-67-4(Hazardous Substances Data)

Usage

Description

4-amino Benzthioamide is a synthetic intermediate useful for pharmaceutical synthesis.

InChI:InChI=1/C7H8N2S/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,8H2,(H2,9,10)

Upstream product

• 873-74-5 4-Aminobenzonitrile 
• 100-01-6 4-nitro-aniline 
• 16106-38-0 4-aminobenzoyl chloride 
• 150-13-0 4-amino-benzoic acid 
• 2835-68-9 4-aminobenzamide 
• 619-72-7 4-nitrobenzonitrile 

Downstream Products

• 6278-73-5 2-(4-aminophenyl)benzothiazole 
• 1095340-49-0 4-(4-(3-methoxyphenyl)thiazol-2-yl)aniline 
• 80370-11-2 4-(4-(4-chlorophenyl)thiazol-2-yl)aniline 
• 749151-25-5 4-(4-(4-methoxyphenyl)thiazol-2-yl)aniline 
• 1424328-64-2 C₈H₆N₂OS₂ 
• 1313750-95-6 BrH*C₁₅H₁₁N₅S 
• 533867-50-4 (R)-N-(2-hydroxy-2-pyridin-3-yl-ethyl)-2-(4-{4-[4-trifluoromethyl-phenyl-thiazol-2-yl]-benzenesulfonylamino}-phenyl)-acetamide 
• 446883-84-7 4-[4-(4-trifluoromethyl-phenyl)-thiazol-2-yl]-bezenesulfonyl chloride 

Relevant articles and documents

Efficient Synthesis and Bioevaluation of Novel Dual Tubulin/Histone Deacetylase 3 Inhibitors as Potential Anticancer Agents

Novel dual HDAC3/tubulin inhibitors were designed and efficiently synthesized by combining the pharmacophores of SMART (tubulin inhibitor) and MS-275 (HDAC inhibitor), among which compound 15cwas found to be the most potent and balanced HDAC3/tubulin dual inhibitor with high HDAC3 activity (IC50= 30 nM) and selectivity (SI > 1000) as well as excellent antiproliferative potency against various cancer cell lines, including an HDAC-resistant gastric cancer cell line (YCC3/7) with IC50values in the range of 30-144 nM. Compound 15cinhibited B16-F10 cancer cell migration and colony formation. In addition, 15cdemonstrated significantin vivoantitumor efficacy in a B16-F10 melanoma tumor model with a better TGI (70.00%, 10 mg/kg) than that of the combination of MS-275 and SMART. Finally, 15cpresented a safe cardiotoxicity profile and did not cause nephro-/hepatotoxicity. Collectively, this work shows that compound 15crepresents a novel tubulin/HDAC3 dual-targeting agent deserving further investigation as a potential anticancer agent.

3H-1,2,4-Dithiazol-3-one compounds as novel potential affordable antitubercular agents

Small molecules with oxathiazol-2-one moiety were recently reported as potent inhibitors of Mycobacterium bovis var. bacilli Calmette-Guérin (BCG), among which HT1171 was the most potent and selective proteasome inhibitor. Herein we synthesized a series of novel compounds by bioisosteric replacement of the oxathiazol-2-one ring with 3H-1,2,4-dithiazol-3-one, and also fifteen 1,3,4-oxathiazol-2-one molecules in order for potency comparison and structure-activity relationship elucidation since their antibacterial effects on the virulent strains were not evaluated before. All the compounds were assessed for antitubercular activities on the virulent H37Rv strain by a serial dilution method. Among the tested compounds, 3H-1,2,4-dithiazol-3-one compound 4n was found to be the most active with a lowest MIC90 value of 1 μg/mL. Furthermore, the cytotoxicities of all the compounds against normal human liver cell line L02 were determined by an MTT method. Compound 4n displayed a lower inhibitory ratio than HT1171 at the concentration of 100 μM, indicating its better safety profile.

Studies on organophosphorus compounds. XXI. The dimer of p-methoxyphenylthionophosphine sulfide as thiation reagent. A new route to thiocarboxamides

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