2835-68-9Relevant articles and documents
The reduction of aromatic nitro groups on solid supports using sodium hydrosulfite (Na2S2O4)
Scheuerman,Tumelty
, p. 6531 - 6535 (2000)
An improved method for reducing aromatic nitro compounds on solid-phase supports using sodium hydrosulfite is presented. Conditions have been optimized to enable the use of this reagent for reductions on both polyethyleneglycol-polystyrene (PEG) resins an
RhNPs/SBA-NH2: A high-performance catalyst for aqueous phase reduction of nitroarenes to aminoarenes at room temperature
Ganji, Saidulu,Enumula, Siva Sankar,Marella, Ravi Kumar,Rao, Kamaraju Seetha Rama,Burri, David Raju
, p. 1813 - 1819 (2014)
A RhNPs/SBA-NH2 catalyst with 2) as support, rhodium acetyl acetonate as a Rh precursor and sodium borohydride (NaBH4) as a re
Industrial Cunninghamia lanceolata carbon supported FeO(OH) nanoparticles-catalyzed hydrogenation of nitroarenes
Fu, Lihua,Li, Dingzhong,Lu, Hao,Qiu, Renhua,Sun, Tulai,Xing, Chen,Yang, Tianbao
, (2022/01/11)
The development of green and efficient methods for hydrogenation of nitroarenes is still highly demanding in organic synthesis. Herein, we report an industrial Cunninghamia lanceolata carbon supported FeO(OH) nanoparticles process for the synthesis of aryl amines with good yields via hydrogenation of nitroarenes. Nine key anti-cancer drug intermediates were successfully achieved with protocol. And Osimertinib intermediate 4m can be smoothly synthesized at a 2.67 kg-scale with >99.5% HPLC purity. This protocol features cheap carbon source, highly catalytic activity, simple operation, kilogram-scalable and recyclable catalysts (eight times without observable losing activity).
Highly efficient hydrogenation reduction of aromatic nitro compounds using MOF derivative Co-N/C catalyst
Dai, Yuyu,Li, Xiaoqing,Wang, Likai,Xu, Xiangsheng
, p. 22908 - 22914 (2021/12/24)
The direct hydrogenation reduction of aromatic nitro compounds to aromatic amines with non-noble metals is an attractive area. Herein, the pyrolysis of Co(2-methylimidazole)2 metal-organic framework successfully produces a magnetic Co-N/C nanocomposite, which exhibits a porous structure with a high specific area and uniform Co nanoparticle distribution in nitrogen-doped graphite. In addition, the Co-N/C catalysts possess high cobalt content (23%) with highly active β-Co as the main existing form and high nitrogen content (3%). These interesting characteristics endow the Co-N/C nanocomposite with excellent catalytic activity for the hydrogenation reduction of nitro compounds under mild conditions. In addition, the obtained Co-N/C nanocomposites possess a broad substrate scope and good cycle stability for the reduction of halogen-substituted or carbonyl substituted phenyl nitrates. This journal is
Biorenewable carbon-supported Ru catalyst for: N -alkylation of amines with alcohols and selective hydrogenation of nitroarenes
Goyal, Vishakha,Narani, Anand,Natte, Kishore,Poddar, Mukesh Kumar,Ray, Anjan,Sarki, Naina,Tripathi, Deependra
, p. 14687 - 14694 (2021/08/23)
Herein, we developed a renewable carbon-supported Ru catalyst (Ru/PNC-700), which was facilely prepared via simple impregnation followed by the pyrolysis process. The prepared Ru/PNC-700 catalyst demonstrated remarkable catalytic activity in terms of conversion and selectivity towards N-alkylation of anilines with benzyl alcohol and chemoselective hydrogenation of aromatic nitro compounds. In addition, local anesthetic pharmaceutical agents (e.g., butamben and benzocaine), including key drug intermediates, were synthesized in excellent yields under mild conditions and in the presence of water as a green solvent. Moreover, the prepared Ru/PNC-700 catalyst could be easily recovered and reused up to five times without any apparent loss in activity and selectivity.