4751-61-5

Basic information

• Product Name: 4,6,7,8-TETRAHYDRO-THIENO[3,2-B]AZEPIN-5-ONE
• Synonyms: 4,6,7,8-TETRAHYDRO-THIENO[3,2-B]AZEPIN-5-ONE;7,8-Dihydro-4H-thieno[3,2-b]azepin-5(6H)-one
• CAS NO: 4751-61-5
• Molecular Formula: C8H9NOS
• Molecular Weight: 167.23
• Mol File: 4751-61-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 4,6,7,8-TETRAHYDRO-THIENO[3,2-B]AZEPIN-5-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6,7,8-TETRAHYDRO-THIENO[3,2-B]AZEPIN-5-ONE(4751-61-5)
• EPA Substance Registry System: 4,6,7,8-TETRAHYDRO-THIENO[3,2-B]AZEPIN-5-ONE(4751-61-5)

Safety Data

• Hazardous Substances Data: 4751-61-5(Hazardous Substances Data)

Usage

Description

4,6,7,8-TETRAHYDRO-THIENO[3,2-B]AZEPIN-5-ONE is a chemical compound belonging to the class of azepines, which are part of the larger group of azacyclic compounds. This specific compound features a thieno ring fused to an azepine ring and is known for its potential applications in the pharmaceutical industry due to its unique structural properties.

Uses

Used in Pharmaceutical Industry:
4,6,7,8-TETRAHYDRO-THIENO[3,2-B]AZEPIN-5-ONE is used as a reactant for the preparation of N-?[4-?[(4,?5-?dihydropyrazolo[3,?4-?d]?thieno[3,?2-?b]?azep in-?6(2H)?-?yl)?carbonyl]?phenyl]?benzamides. These compounds serve as arginine vasopressin (AVP) receptor antagonists, which have potential applications in the treatment of various medical conditions related to the regulation of water balance in the body, such as diabetes insipidus and heart failure.

Upstream product

• 94252-22-9 6,7-dihydro-5H-benzo[b]thiophene-4-one O-tosyloxime 
• 13414-95-4 4-keto-4,5,6,7-tetrahydrothianaphthene 
• 19995-19-8 4,5,6,7-tetrahydro-4-oxobenzo[b]thiophene oxime 

Downstream Products

• 180340-57-2 5,6,7,8-tetra-hydro-4H-thieno[3,2-b]azepine 
• 190276-75-6 (3-Methoxy-4-nitro-phenyl)-(5,6,7,8-tetrahydro-thieno[3,2-b]azepin-4-yl)-methanone 

Relevant articles and documents

NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS

Compounds of Formula (I) are HIV reverse transcriptase inhibitors, wherein X, R1, R2, R3, R4 and R5 are defined herein. The compounds of Formula (I) and their pharmaceutically acceptable salts are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Regioselective synthesis of several heterocyclic fused azepines using diisobutylaluminum hydride

5,6,7,8-Tetrahydrothieno[3,2-b]azepine,5,6,7,8-tetrahydro-1H-furo[3,2-b] azepine, and 1,4,5,6,7,8-hexahydropyrrolo[3,2-b]azepine were synthesized by the ring expansion reaction of heterocyclic fused cyclohexanone oximes with diisobutylaluminum hydride (DIBAH). The mechanism of the reaction was different from that of Beckmann rearrangement.

Heterocyclic-fused lactams promote release of growth hormone

There are disclosed certain novel compounds identified as heterocyclic-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible