180340-57-2

Basic information

• Product Name: 5,6,7,8-TETRAHYDRO-4H-THIENO[3,2-B]AZEPINE
• Synonyms: 5,6,7,8-TETRAHYDRO-4H-THIENO[3,2-B]AZEPINE
• CAS NO: 180340-57-2
• Molecular Formula: C₈H₁₁NS
• Molecular Weight: 153.24
• Mol File: 180340-57-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 279.215 °C at 760 mmHg
• Flash Point: 122.665 °C
• Appearance: /
• Density: 1.098 g/cm³
• CAS DataBase Reference: 5,6,7,8-TETRAHYDRO-4H-THIENO[3,2-B]AZEPINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6,7,8-TETRAHYDRO-4H-THIENO[3,2-B]AZEPINE(180340-57-2)
• EPA Substance Registry System: 5,6,7,8-TETRAHYDRO-4H-THIENO[3,2-B]AZEPINE(180340-57-2)

Safety Data

• Hazardous Substances Data: 180340-57-2(Hazardous Substances Data)

Usage

General Description

5,6,7,8-TETRAHYDRO-4H-THIENO[3,2-B]AZEPINE is a chemical compound with a molecular formula of C8H11NS. It is a bicyclic heterocyclic compound that contains a thiophene ring fused with an azepine ring. This chemical is used in the pharmaceutical industry as a building block for the synthesis of various drugs, including antipsychotics and antidepressants. It has also been studied for its potential antiviral and antiproliferative properties. Additionally, 5,6,7,8-TETRAHYDRO-4H-THIENO[3,2-B]AZEPINE has been investigated for its potential use in the treatment of substance abuse and addiction. Overall, this compound has garnered interest in medicinal chemistry for its diverse range of potential applications.

Upstream product

• 19995-19-8 4,5,6,7-tetrahydro-4-oxobenzo[b]thiophene oxime 
• 137046-61-8 4H-thieno<3,2-b>azepine-5,8(6H,7H)-dione 
• 4751-61-5 4,6,7,8-Tetrahydro-4H-thieno[3,2-b]azepin-5-one 
• 13414-95-4 4-keto-4,5,6,7-tetrahydrothianaphthene 
• 13292-87-0 dimethyl sulfide borane 
• 137046-59-4 3-(3-Methoxycarbonyl-propionylamino)-thiophene-2-carboxylic acid methyl ester 
• 94252-22-9 6,7-dihydro-5H-benzo[b]thiophene-4-one O-tosyloxime 

Downstream Products

• 190276-75-6 (3-Methoxy-4-nitro-phenyl)-(5,6,7,8-tetrahydro-thieno[3,2-b]azepin-4-yl)-methanone 
• 180340-58-3 (4-nitrophenyl)(5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepin-4-yl)methanone 
• 180992-33-0 4-(2-Chloro-4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine 
• 190276-81-4 (2-methoxy-4-nitro-phenyl)-(5,6,7,8-tetrahydro-thieno[3,2-b]azepin-4-yl)-methanone 
• 180340-59-4 4-(4-Nitrobenzoyl)-4,5,6,7-tetrahydro-8H-thieno[3,2-b]-azepin-8-one 
• 180992-34-1 4-(2-chloro-4-aminobenzoyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine 
• 180992-32-9 2-chloro-4-(4-aminobenzoyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine 
• 180340-61-8 2-Chloro-4-(4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine 
• 276867-99-3 6-(4-aminobenzoyl)pyrazolo[3,4-d]thieno[3,2-b]azepine 
• 180992-35-2 4,5,6,7-tetrahydro-4-(2-chloro-4-nitrobenzoyl)-8H-thieno[3,2-b]azepin-8-one 
• 180340-33-4 2,4,5,6-tetrahydro-2-methyl-6-(4-aminobenzoyl)pyrazolo[3,4-d]thieno[3,2-b]azepine 
• 180339-72-4 7-[(dimethylamino)methylene]-4,5,6,7-tetrahydro-4-(4-nitrobenzoyl)-8H-thieno [3,2-b]azepin-8-one 
• 276867-97-1 C₁₇H₁₄N₄O₃S 
• 276868-00-9 C₁₆H₁₃ClN₄OS 

Relevant articles and documents

Ring-expansion reaction of oximes with aluminum reductants

The ring-expansion reactions of heterocyclic ketoximes and carbocyclic ketoximes with several reductants such as AlHCl2, AlH3 (alane), LiAlH4, LiAlH(OtBu)3, and (MeOCH 2CH2O)2AlH2Na (Red-Al) were examined. Among reductants, AlHCl2 (LiAlH4:AlCl 3 = 1:3) in cyclopentyl methyl ether (CPME) has been found to be a suitable reagent for the reaction, and the rearranged cyclic secondary amines were obtained in good to excellent yields.

Non-peptide oxytocin agonists

The first non-peptide, low molecular weight agonists of the hormone oxytocin (OT) are reported. The most potent compound, 39, showed an EC 50 = 33 nM and was selective for the OT receptor. A library of compounds targeted to the vasopressin/oxytocin family of receptors was screened for activity at a cloned human oxytocin receptor using a reporter gene assay. Potency and selectivity were optimised to afford compound 39, EC50 = 33 nM. This series of compounds represents the first disclosed, non-peptide, low molecular weight agonists of the hormone oxytocin (OT).

Biphenyl vasopressin agonists

A compound of the formulae (I) or (II): wherein: Y is a moiety selected from NR or —(CH2)n; wherein R is hydrogen or (C1-C6) lower alkyl, and n is 1; represents: (1) a phenyl ring optionally substituted with one