476360-70-0

Basic information

• Product Name: isobutyric acid 4-[3-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)-8-oxo-5,8-dihydro-3H-1,3,4,5,7a-pentaaza-s-indacen-6-yl]-phenyl ester
• Synonyms: isobutyric acid 4-[3-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)-8-oxo-5,8-dihydro-3H-1,3,4,5,7a-pentaaza-s-indacen-6-yl]-phenyl ester
• CAS NO: 476360-70-0
• Molecular Weight: 441.444
• Mol File: 476360-70-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: isobutyric acid 4-[3-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)-8-oxo-5,8-dihydro-3H-1,3,4,5,7a-pentaaza-s-indacen-6-yl]-phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: isobutyric acid 4-[3-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)-8-oxo-5,8-dihydro-3H-1,3,4,5,7a-pentaaza-s-indacen-6-yl]-phenyl ester(476360-70-0)
• EPA Substance Registry System: isobutyric acid 4-[3-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)-8-oxo-5,8-dihydro-3H-1,3,4,5,7a-pentaaza-s-indacen-6-yl]-phenyl ester(476360-70-0)

Safety Data

• Hazardous Substances Data: 476360-70-0(Hazardous Substances Data)

Upstream product

• 99-93-4 4-Hydroxyacetophenone 
• 82410-32-0 ganciclovir 
• 476360-57-3 4-isobutyryloxyphenacyl bromide 
• 75305-81-6 4-isobutyryloxyacetophenone 

Downstream Products

• 929258-15-1 3-(2,2-dimethyl-[1,3]dioxan-5-yloxymethyl)-6-(4-hydroxy-phenyl)-3,5-dihydro-1,3,4,5,7a-pentaaza-s-indacen-8-one 
• 929258-13-9 3-(2,2-dimethyl-[1,3]dioxan-5-yloxymethyl)-6-(4-hydroxy-phenyl)-8-oxo-3,8-dihydro-1,3,4,5,7a-pentaaza-s-indacene-5-carboxylic acid tert-butyl ester 
• 929258-19-5 C₅₅H₇₃N₇O₁₁S₂ 

Relevant articles and documents

Synthesis of a technetium-99m labeled tricyclic ganciclovir analog for non-invasive reporter gene expression imaging

A potential radiopharmaceutical and HSV1-TK substrate, 3-((1,3-dihydroxypropan-2-yloxy)-methyl)-6-(4-(3-((2-mercaptoethyl)(2-(2-mercaptoethyl-amino)-ethyl)amino)propoxy)phenyl)-3H-imidazopurin-9(5H)-one-oxo-technetium(V), was synthesized via a converging

Synthesis and biological activity of strongly fluorescent tricyclic analogues of acyclovir and ganciclovir

In search of strongly fluorescent tricyclic analogues of acyclovir (ACV, 1) and ganciclovir (GCV, 2), derivatives of the 3,9-dihydro-9-oxo-5H-imidazo[1,2-α]purine system, several 6-[4- (acyloxy)-phenyl], 6-[4-(acylamino)phenyl], and 6-[4-(phenoxycarbonyloxy)phenyl]-substituted TACV and TGCV analogues were synthesized and evaluated for their activity against herpes simplex virus types 1 and 2 in cell culture. All TACV and TGCV analogues showed strong fluorescence (quantum yield of 30-65% vs 2-aminopurine 100%). The 6-[4-(phenoxycarbonyloxy)phenyl]-substituted compounds 11 and 19 displayed the best combination of the fluorescence and antiviral potency.