477884-78-9

Basic information

• Product Name: Latanoprost Tris(triethylsilyl) Ether
• Synonyms: Latanoprost Tris(triethylsilyl) Ether;(5Z)-7-[(1R,2R,3R,5S)-2-[(3R)-5-Phenyl-3-[(triethylsilyl)oxy]pentyl]-3,5-bis[(triethylsilyl)oxy]cyclopentyl]-5-heptenoic Acid 1-Methylethyl Ester;Latanoprost Related CoMpound D;Latanoprost Related Compound D (25 mg) (Isopropyl (Z)-7-{(1R,2R,3R,5S)-2-[(R)-5-phenyl-3-(triethylsilyloxy)pentyl]-3,5-bis(triethylsilyloxy)cyclopentyl}hept-5-enoate)
• CAS NO: 477884-78-9
• Molecular Formula: C44H82O5Si3
• Molecular Weight: 775.37538
• Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 477884-78-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Acetonitrile (Sparingly, Heated, Sonicated), Chloroform (Slightly)
• CAS DataBase Reference: Latanoprost Tris(triethylsilyl) Ether(CAS DataBase Reference)
• NIST Chemistry Reference: Latanoprost Tris(triethylsilyl) Ether(477884-78-9)
• EPA Substance Registry System: Latanoprost Tris(triethylsilyl) Ether(477884-78-9)

Safety Data

• Hazardous Substances Data: 477884-78-9(Hazardous Substances Data)

Usage

Description

Latanoprost Tris(triethylsilyl) Ether is a derivative of Latanoprost, which is a prostaglandin analog used in the treatment of glaucoma and ocular hypertension. It is characterized by its tris(triethylsilyl) ether functional group, which may contribute to its unique properties and potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
Latanoprost Tris(triethylsilyl) Ether is used as a pharmaceutical compound for its potential ocular hypotensive effects. As a Latanoprost derivative, it may offer similar benefits in reducing intraocular pressure, which is crucial for managing glaucoma and preventing vision loss.
Used in Research and Development:
Latanoprost Tris(triethylsilyl) Ether is used as a research compound for studying the structure-activity relationship of prostaglandin analogs. Its unique chemical structure may provide insights into the development of new and improved drugs for glaucoma treatment and other ocular conditions.
Used in Quality Control:
Latanoprost Tris(triethylsilyl) Ether is used as a reference standard or related compound in the quality control and standardization of pharmaceutical products containing Latanoprost. It helps ensure the purity, potency, and consistency of these medications, contributing to their safety and efficacy.

Upstream product

• 128948-09-4 (-)-7α-triethylsilyloxy-6β-triethylsilyloxymethyl-cis-2-oxabicyclo<3.3.0>octan-3-one 
• 128948-10-7 (-)-7α-triethylsilyloxy-6β-formyl-cis-2-oxabicyclo<3.3.0>octan-3-one 
• 2550-26-7 4-Phenyl-2-butanone 
• 994-30-9 triethylsilyl chloride 
• 31984-10-8 1-bromo-4-phenylbutan-2-one 
• 352276-27-8 1-iodo-4-phenylbutan-2-one 
• 41162-19-0 dimethyl(2-oxo-4-phenylbutyl)phosphonate 
• 32233-40-2 (3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one 

Relevant articles and documents

A Facile and Efficient Synthesis of (15R)-Latanoprost from Chiral Precursor Corey Lactone Diol

An efficient asymmetric synthetic route for the synthesis of anti-glaucoma agent, (15R)-latanoprost using Corey lactone diol as chiral substrate under Swern oxidation, allylic reduction and Wittig reaction conditions has been developed. In this method, reduction of keto and alkene functional groups has been achieved in a single step using low cost catalyst NiCl2/NaBH4 in methanol. This new synthetic protocol is a good alternative for the synthesis of latanoprost with high stereo selectivity and improved yield. [Figure not available: see fulltext.]