4779-36-6Relevant articles and documents
Manufacturing method of piperidinyl sulfonyl sulfonamide
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Paragraph 0053-0057, (2021/01/29)
The present invention relates to the preparation of diphenylsulfonylamide represented by formula 1. Chemically 1 _AOMARKENCODEGTX06017. A compound represented by chemical formula 2 is obtained by reacting a compound represented by chemical formula 3 with N-protected piperidine amine to obtain a compound represented by the following formula, wherein N is protected with N-protected piperidine amine to obtain a compound represented by chemical formula 4 6, and to obtain a compound represented by the 6 7 formula 5 of the compound represented by the following general formula in the following 7 chemical formula 5 to obtain a compound represented by the following general formula (1 I). AOMARKENCODELTX017. Chemically 2 _AOMARKENCODEGTX06017. AOMARKENCODELTX017. Chemically 3 _AOMARKENCODEGTX06017. AOMARKENCODELTX017. Chemically 4 _AOMARKENCODEGTX06017. AOMARKENCODELTX017. Chemically 5 _AOMARKENCODEGTX06017. AOMARKENCODELTX017. Chemically 6 _AOMARKENCODEGTX06017. AOMARKENCODELTX017. Chemically 7 _AOMARKENCODEGTX06017.
Modulation of Wnt signaling through inhibition of secreted frizzled-related protein i (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides
Moore, William J.,Kern, Jeffrey C.,Bhat, Ramesh,Commons, Thomas J.,Fukayama, Shoichi,Goljer, Igor,Krishnamurthy, Girija,Magolda, Ronald L.,Nogle, Lisa,Pitts, Keith,Stauffer, Barb,Trybulski, Eugene J.,Welmaker, Gregory S.,Wilson, Matthew,Bodine, Peter V. N.
experimental part, p. 105 - 116 (2009/08/07)
The diphenylsulfonyl sulfonamide scaffold represented by 1 (WAY-316606) are small molecule inhibitors of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. Modulators of the Wnt pathway have been proposed as anabolic a
2H-Benzimidazoles (Isobenzimidazoles). Part 3. Thermal Isomerisation of Substituted 2H-Benzimidazoles to 1H-Benzimidazoles
Herbert, John A. L.,Iddon, Brian,Robinson, Andrew G.,Suschitzky, Hans
, p. 991 - 998 (2007/10/02)
2H-Benzimidazole-2-spirocyclohexanes (1) when heated undergo a 1,5-sigmatropic rearrangement to 2,3-disubstituted 1H-benzimidazoles.A decided effect on the direction of this isomerisation was observed with substituents in the homodiene ring.