98-60-2Relevant articles and documents
Facile synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazides
Chen, Rongxiang,Xu, Shaohong,Shen, Fumin,Xu, Canran,Wang, Kaikai,Wang, Zhanyong,Liu, Lantao
, (2021/09/20)
A simple and rapid method for efficient synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazide with NXS (X = Cl or Br) and late-stage conversion to several other functional groups was described. A variety of nucleophiles could be engaged in this transformation, thus permitting the synthesis of complex sulfonamides and sulfonates. In most cases, these reactions are highly selective, simple, and clean, affording products at excellent yields.
Preparation method of medical intermediate of parachlorobenzenesulfonyl chloride
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Page/Page column 4-6, (2019/03/08)
The invention discloses a preparation method of a medical intermediate of parachlorobenzenesulfonyl chloride. The preparation method specifically comprises the following steps: firstly, cyclodextrin is modified sequentially through maleic anhydride and tetradecyl trimethyl ammonium chloride, and the modified cyclodextrin is obtained; and then a reaction is conducted by adopting sodium 4-chlorobenzenesulfonate and thionyl chloride as raw materials and the modified cyclodextrin as a catalyst, and by being added with ammonium trifluoroacetate for assisting. The prepared medical intermediate of the parachlorobenzenesulfonyl chloride is high in yield and high in purity, the reacting conditions are easy to operate, the requirements for equipment are low, and control is easy.
Preparation method of 4-chlorothiophenol
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Paragraph 0016; 0018, (2018/04/26)
The invention relates to a simple preparation method of 4-chlorothiophenol. 4-chlorobenzenesulfonyl chloride is prepared from sodium 4-chlorobenzenesulfonate and thionyl chloride as raw materials andtoluene as a solvent through a reaction at 50-70 DEG C for 3-5 h under the action of a phase transfer catalyst and reduced by iron powder at the temperature of 40-60 DEG C under an acidic condition, and 4-chlorothiophenol is obtained. The method has the characteristics of being low in cost, simple and convenient to operate and suitable for industrial production.