4783-68-0

Basic information

• Product Name: 2-PHENOXYPYRIDINE
• Synonyms: 2-PHENOXYPYRIDINE;PHENYL 2-PYRIDYL ETHER;2-Pyridylphenyl ether
• CAS NO: 4783-68-0
• Molecular Formula: C₁₁H₉NO
• Molecular Weight: 171.2
• EINECS: 225-328-3
• Product Categories: Heterocycle-Pyridine series
• Mol File: 4783-68-0.mol
• Article Data: 49

Chemical Properties

• Boiling Point: 274.4°Cat760mmHg
• Flash Point: 100.6°C
• Appearance: /
• Density: 1.117g/cm³
• Vapor Pressure: 0.00906mmHg at 25°C
• Refractive Index: 1.577
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.59±0.12(Predicted)
• CAS DataBase Reference: 2-PHENOXYPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENOXYPYRIDINE(4783-68-0)
• EPA Substance Registry System: 2-PHENOXYPYRIDINE(4783-68-0)

Safety Data

• Hazardous Substances Data: 4783-68-0(Hazardous Substances Data)

Usage

General Description

2-PhenoxyPyridine is a chemical compound with the molecular formula C11H9NO. It is a pale yellow liquid with a faint odor that is commonly used as an intermediate in the synthesis of pharmaceuticals, pesticides, and other organic compounds. 2-PhenoxyPyridine is also known for its use as a reagent in organic chemical reactions, such as the formation of carbon-nitrogen bonds in the production of heterocyclic compounds. It is considered to have low toxicity and is not known to have any significant harmful effects on human health or the environment when used in accordance with safe handling practices. However, prolonged or excessive exposure to 2-PhenoxyPyridine should be avoided to prevent any potential health risks.

InChI:InChI=1/C11H9NO/c1-2-6-10(7-3-1)13-11-8-4-5-9-12-11/h1-9H

Upstream product

• 109-04-6 2-bromo-pyridine 
• 139-02-6 sodium phenoxide 
• 108-95-2 phenol 
• 100-67-4 potassium phenolate 
• 372-48-5 2-fluoropyridine 
• 2127-03-9 2,2'-dipyridyldisulphide 
• 41122-56-9 sodium pyridine-2-diazotate 
• 109-09-1 2-chloropyridine 
• 5029-67-4 2-iodopyridine 
• 142-08-5 2-Pyridone 
• 591-50-4 iodobenzene 
• 501378-40-1 6-phenoxypicolinonitrile 
• 462-80-6 benzyne 
• 66715-65-9 pyridine-2-sulfonyl chloride 

Downstream Products

• 51954-54-2 2-(p-tolylthio)pyridine 
• 108-95-2 phenol 
• 142-08-5 2-Pyridone 
• 220693-30-1 [AuCl₃(NC₅H₄(OC₆H₅))] 
• 220693-28-7 C₅H₅N(OC₆H₅)⁽¹⁺⁾*AuCl₄^(1-) = [C₅H₅N(OC₆H₅)][AuCl₄] 
• 1173294-99-9 (3,5-dichlorophenyl)(2-(pyridin-2-yloxy)phenyl)methanone 
• 1173294-97-7 (2-(pyridin-2-yloxy)phenyl)(p-tolyl)methanone 
• 1173294-85-3 phenyl(2-(pyridin-2-yloxy)phenyl)methanone 
• 1173294-98-8 (4-bromophenyl)(5-methoxy-2-(pyridin-2-yloxy)phenyl)methanone 
• 1357293-53-8 2-(2-fluorophenoxy)pyridine 
• 2943-42-2 di(4-methyl)phenylthiosulfonate 

Relevant articles and documents

A CONVENIENT METHOD FOR THE PREPARATION OF 6-PHENOXY-2-PYRIDINECARBALDEHYDE

6-Phenoxy-2-pyridinecarbaldehyde was prepared in good yields through a few reaction steps utilizing Grignard reaction which has been regarded disadvantageous for preparation of pyridinecarbaldehydes.

Ligand compound for copper catalyzed aryl halide coupling reaction, catalytic system and coupling reaction

The invention provides a ligand compound capable of being used for copper catalyzed aryl halide coupling reaction, the ligand compound is a three-class compound containing a 2-(substituted or non-substituted) aminopyridine nitrogen-oxygen group, and the invention also provides a catalytic system for the aryl halide coupling reaction. Thecatalytic system comprises a copper catalyst, a compound containing a 2-(substituted or non-substituted) aminopyridine nitrogen-oxygen group adopted as a ligand, alkali and a solvent, and meanwhile, the invention also provides a system for the aryl halide coupling reaction adopting the catalyst system. The compound containing the 2-(substituted or non-substituted) aminopyridine nitrogen oxygen group can be used as the ligand for the copper catalyzed aryl chloride coupling reaction, and the ligand is stable under a strong alkaline condition and can well maintain catalytic activity when being used for the copper-catalyzed aryl chloride coupling reaction. In addition, the copper catalyst adopting the compound as the ligand can particularly effectively promote coupling of copper catalyzed aryl chloride and various nucleophilic reagents which are difficult to generate under conventional conditions, C-N, C-O and C-S bonds are generated, and numerous useful small molecule compounds are synthesized. Therefore, the aryl halide coupling reaction has a very good large-scale application prospect by adopting the copper catalysis system of the ligand.

N - And O -arylation of pyridin-2-ones with diaryliodonium salts: Base-dependent orthogonal selectivity under metal-free conditions

Metal-free N- and O-arylation reactions of pyridin-2-ones as ambident nucleophiles have been achieved with diaryliodonium salts on the basis of base-dependent chemoselectivity. In the presence of N,N-diethylaniline in fluorobenzene, pyridin-2-ones were very selectively converted to N-arylated products in high yields. On the other hand, the O-arylation reactions smoothly proceeded with the use of quinoline in chlorobenzene, leading to high yields and selectivities. In these methods, a variety of pyridin-2-ones in addition to pyridin-4-one and a set of diaryliodonium salts were accepted as suitable reaction partners.

Ruthenium-Catalyzed meta-CAr–H Bond Difluoroalkylation of 2-Phenoxypyridines

A ruthenium-catalyzed meta-selective CAr–H bond difluoroalkylation of 2-phenoxypyridine using 2-bromo-2,2-difluoroacetate has been developed. Mechanistic studies indicated that this difluoroalkylation might involve a radical process. Furthermore, a new method is reported for the synthesis of 2-(meta-difluoroalkylphenoxy)pyridine derivatives, which are present in many pharmaceuticals and other functional compounds.