480450-69-9

Basic information

• Product Name: Carbamic acid, [(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexyl]-, 1,1-dimethylethyl ester
• CAS NO: 480450-69-9
• Molecular Formula: C14H25N5O3
• Molecular Weight: 311.384
• Mol File: 480450-69-9.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexyl]-, 1,1-dimethylethyl ester(480450-69-9)
• EPA Substance Registry System: Carbamic acid, [(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexyl]-, 1,1-dimethylethyl ester(480450-69-9)

Safety Data

• Hazardous Substances Data: 480450-69-9(Hazardous Substances Data)

Usage

General Description

The chemical "Carbamic acid, [(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexyl]-, 1,1-dimethylethyl ester" is a compound that is used as a base in organic synthesis and in the manufacturing of pharmaceuticals. It is a derivative of carbamic acid and features a cyclohexyl ring with an azide and a dimethylamino carbonyl group attached. The 1,1-dimethylethyl ester group is a common protecting group used in organic chemistry to stabilize reactive functional groups. Carbamic acid, [(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexyl]-, 1,1-dimethylethyl ester may have potential applications in drug development and medicinal chemistry due to its unique structure and reactivity. However, it should be handled with caution due to its potential for toxicity and reactivity.

Upstream product

• 506-59-2 N,N-dimethylammonium chloride 
• 929693-31-2 {(1R,2R,4S)-2-[(tert-butoxycarbonyl)amino]-4-[(dimethylamino)carbonyl]cyclohexyl}methanesulfonate 
• 929693-30-1 (1S,3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-hydroxy-N,N-dimethylcyclohexanecarboxamide 
• 929693-36-7 (1S,3R,4R)-3-amino-4-hydroxy-N,N-dimethyl cyclohexanecarboxamide 
• 929693-35-6 (1S,3S,6R)-N,N-dimethyl-7-oxabicyclo[4.1.0]heptane-3-carboxamide 
• 123536-66-3 (1S,4S,5S)-4-iodo-6-oxabicyclo<3.2.1>octan-7-one 
• 4771-80-6 1,2,5,6-tetrahydrobenzoic acid 
• 365997-34-8 ethyl (1S,3R,4S)-4-azido-3-(tert-butoxycarbonylamino)-cyclohexane-1-carboxylate 
• 365997-33-7 ethyl (1S,3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxycyclohexane-1-carboxylate 
• 929693-34-5 ethyl (1S,3R,4R)-3-amino-4-hydroxycyclohexanecarboxylate 
• 365997-31-5 (1S,3S,6R)-7-oxabicyclo[4.1.0]heptane-3-carboxylic acid ethyl ester 
• 5708-19-0 (1S)-3-cyclohexenecarboxylic acid 
• 365997-36-0 (1S,3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-[(methylsulfonyl)oxy]cyclohexanecarboxylic acid ethyl ester 
• 67976-82-3 (1S)-3-cyclohexene-1-carboxylic acid (R)-(+)-α-methylbenzylamine salt 

Downstream Products

• 480452-36-6 carbamic acid, N-[(1R,2S,5S)-2-[[2-[(5-chloro-2-pyridinyl)amino]-2-oxoacetyl]amino]-5-[(dimethylamino)carbonyl]cyclohexyl]-1,1-dimethylethyl ester 
• 480449-70-5 edoxaban 
• 480449-71-6 [14C]-Edoxaban tosylate 
• 365998-36-3 (1S,2R,4S)-N₂-(tert-butoxycarbonyl)-4-(N,N-dimethylcarbamoyl)-1,2-cyclohexanediamine 
• 480450-70-2 N-{(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexyl}-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide 

Relevant articles and documents

Preparation method of edoxaban chiral azide intermediate compound

The invention provides a preparation method of an edoxaban chiral azide intermediate compound, which comprises the following steps of: performing substitution reaction on a hydroxyl compound as shown in a formula (II) serving as a substrate and an organic azide compound in an organic solvent in the presence of an amidine structure compound to obtain a chiral azide intermediate compound as shown in a formula (I). A two-step synthesis reaction is directly optimized into one-step reaction synthesis, organic azide compounds such as diphenyl azide phosphate, p-toluenesulfonyl azide and azido trimethylsilane are adopted as sources of azide groups, and a substitution reaction is carried out in a proper solvent under the assistance of amidine structure compounds such as methylimidine, DBN, DBU and trinitrogen amidine to obtain a target compound, namely, a chiral azide intermediate. Not only is the use of highly toxic methylsulfonyl chloride and explosive sodium azide successfully avoided, but also the process difficulty and the production cost are reduced.

Method for preparing eteaban chiral amine intermediate (by machine translation)

The invention provides a safe and convenient method for preparing N - [(1R, 2S, 5S) -2 - amino -5 - [(dimethylamino) carbonyl] cyclohexyl] carbamic acid tert-butyl formate. The compound N - [(1R, 2R, 5S) -5 - [(dimethylamino) carbonyl] -2 - hydroxycyclohexyl] carbamic acid tert-butyl carbamate and the DBU azidate are then reacted to obtain N - [(1R, 2R, 5S) -5 - [(dimethylamino) carbonyl] cyclohexyl] carbamic acid tert-butyl formate in the presence of DBU to obtain the corresponding amino. N - [(1R, 2S, 5S) -2 - amino -2 -5 - [(dimethylamino) carbonyl] cyclohexyl] carbamic acid tert-butyl formate in the presence of a DBU to obtain the corresponding amino compound. N - 2S [(dimethylamino) carbonyl] cyclohexyl] carbamic acid tert-butyl formate 1R 5S -2 -5 . (by machine translation)

METHOD FOR PRODUCING (1S,4S,5S)-4-BROMO-6-OXABICYCLO[3.2.1]OCTAN-7-ONE

It is an object of the present invention to provide a method for efficiently producing (1S,4S,5S)-4-bromo-6-oxabicyclo[3.2.1]octan-7-one (1), which is important as an intermediate compound for the production of an FXa-inhibiting compound. A method for producing (1S,4S,5S)-4-bromo-6-oxabicyclo[3.2.1]octan-7-one (1), which comprises treating an (R)-α-phenylethylamine salt of (S)-3-cyclohexene-1-carboxylic acid with 1,3-dibromo-5,5-dimethylhydantoin or N-bromosuccinimide in a solvent.