4806-79-5

Basic information

• Product Name: P-CHLORO-BETA-METHYL-PHENETHYLAMINE HYDROCHLORIDE
• Synonyms: P-CHLORO-BETA-METHYL-PHENETHYLAMINE HYDROCHLORIDE;4-chloro-beta-methylphenethylamine hydrochloride;P-chloro-B-methylphenethylamine*hydrochloride;p-chloro-β-methylphenethylamine hydrochloride;4-chloro-beta-methylphenethylamine;4-Chloro-β-methylbenzeneethanamine;2-(4-Chlorophenyl)propan-1-amine hydrochloride;2-(4-chlorophenyl)propan-1-amine
• CAS NO: 4806-79-5
• Molecular Formula: C₉H₁₂ClN
• Molecular Weight: 206.11
• EINECS: 225-365-5
• Product Categories: Amine Salts;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 4806-79-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 243.3 °C at 760 mmHg
• Flash Point: 116.2 °C
• Appearance: /
• Density: 1.093 g/cm³
• Vapor Pressure: 0.00285mmHg at 25°C
• Storage Temp.: 2-8°C
• PKA: 9.74±0.10(Predicted)
• CAS DataBase Reference: P-CHLORO-BETA-METHYL-PHENETHYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: P-CHLORO-BETA-METHYL-PHENETHYLAMINE HYDROCHLORIDE(4806-79-5)
• EPA Substance Registry System: P-CHLORO-BETA-METHYL-PHENETHYLAMINE HYDROCHLORIDE(4806-79-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 4806-79-5(Hazardous Substances Data)

Usage

General Description

P-Chloro-beta-methyl-phenethylamine hydrochloride is a chemical compound with a molecular formula of C9H13Cl2N. It is a synthetic amphetamine derivative that acts as a central nervous system stimulant and has been used in the past as a potential treatment for attention-deficit hyperactivity disorder (ADHD). However, due to its potential for abuse and dependence, it is a controlled substance in many countries and is not commonly used in medical practice. The compound is known to increase the levels of dopamine and norepinephrine in the brain, leading to increased alertness, concentration, and energy. Its use can also lead to various side effects, including insomnia, anxiety, and increased heart rate and blood pressure.

InChI:InChI=1/C9H12ClN.ClH/c1-7(6-11)8-2-4-9(10)5-3-8;/h2-5,7H,6,11H2,1H3;1H

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Relevant articles and documents

Early Drug-Discovery Efforts towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors

EP300 and CBP (KAT3A/3B) are two highly homologous, multidomain, epigenetic coregulators that play central roles in transcription through the acetylation of lysine residues on histones and other proteins. Both enzymes have been implicated in human diseases, especially cancer. From a high-throughput screen of 191 000 compounds searching for EP300/CBP histone acetyltransferase (HAT) inhibitors, 18 compounds were characterized by a suite of biochemical enzymatic assays and biophysical methods, including X-ray crystallography and native mass spectrometry. This work resulted in the discovery of three distinct mechanistic classes of EP300/CBP HAT inhibitors, including two classes not previously described. The profiles of an example of each class of inhibitor are described in detail. A subsequent medicinal chemistry effort led to the development of a novel class of orally bioavailable AcCoA-competitive EP300/CBP HAT inhibitors with in vivo activity. We believe that this work will prove to be a useful guide for other groups interested in the development of HAT inhibitors.

NEW COMPOUNDS I/418

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Asymmetric Hydrogenation of 2-Aryl-1-nitropropenes by Fermenting Bakers'Yeast

2-Aryl-1-nitropropenes were enantioselectively hydrogenated on C=C double bonds by incubation with fermenting bakers' yeast to afford optically active 2-aryl-1-nitopropanes.