488828-89-3

Basic information

• Product Name: Benzenamine, 4-chloro-2-[1-(2-fluorophenyl)ethenyl]-
• CAS NO: 488828-89-3
• Molecular Formula: C14H11ClFN
• Molecular Weight: 247.699
• Mol File: 488828-89-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzenamine, 4-chloro-2-[1-(2-fluorophenyl)ethenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 4-chloro-2-[1-(2-fluorophenyl)ethenyl]-(488828-89-3)
• EPA Substance Registry System: Benzenamine, 4-chloro-2-[1-(2-fluorophenyl)ethenyl]-(488828-89-3)

Safety Data

• Hazardous Substances Data: 488828-89-3(Hazardous Substances Data)

Upstream product

• 1779-49-3 Methyltriphenylphosphonium bromide 
• 784-38-3 2-amino-5-chloro-2'-fluorobenzophenone 

Downstream Products

• 488828-91-7 [2-(2-amino-5-chloro-phenyl)-2-(2-fluoro-phenyl)-ethylsulfanyl]-acetic acid methyl ester 
• 67960-31-0 5-chloro-3-(2-fluorophenyl)-1H-indole 

Relevant articles and documents

Catalyst-free and selective trifluoromethylative cyclization of acryloanilides using PhICF3Cl

Trifluoromethylation-triggered cyclization of alkenes provides a useful route to CF3-containing cyclic compounds. Current approaches to generate CF3-based initiators from a CF3 source require a catalyst or an activator. This work describes a catalyst-free protocol to innately produce electrophilic CF3 species from PhICF3Cl for trifluoromethylative cyclization of acryloanilides. A new domino biscyclization of dienes has been developed leading to trifluoroethylated tetrahydroindenoquinolinones with chemo- and stereo-selectivity.

Palladium-catalyzed cascade reactions of alkene-tethered carbamoyl chlorides with: N-tosyl hydrazones: Synthesis of alkene-functionalized oxindoles

A palladium-catalyzed cascade reaction of alkene-tethered carbamoyl chlorides with N-tosyl hydrazones is described. It provided a new way to synthesize various alkene-functionalized oxindoles bearing an all-carbon quaternary center. The olefin moieties co

Iron-Promoted Construction of Indoles via Intramolecular Oxidative C-N Coupling of 2-Alkenylanilines Using Persulfate

Indole scaffold synthesis relies primarily on oxidative C-H amination of N-protected alkenylanilines for C-N intramolecular cyclization reactions. Herein, for the first time, without N-protection, various readily prepared 2-alkenylanilines were transformed into the desired indole products in good yields by using K 2 S 2 O 8 as oxidant in the presence of catalytic amounts of FeF 2. The K 2 S 2 O 8 /FeF 2 system offers a direct and benign synthetic route to 3-arylindoles and it is applicable to a wide range of substituted indoles including drug intermediates.