4892-10-8Relevant articles and documents
An efficient amide-forming reaction using tributyltrichloromethylphosphonium chloride
Lorca,Kurosu
, p. 469 - 473 (2001)
An efficient and expeditious amide-forming reaction is described via a combination of tributylphosphine and carbon tetrachloride (in situ generation of tributyltrichloromethylphosphonium chloride) in the absence of tertiary amines.
Mechanochemical Synthesis of Dipeptides Using Mg-Al Hydrotalcite as Activating Agent under Solvent-Free Reaction Conditions
Landeros, José M.,Juaristi, Eusebio
, p. 687 - 694 (2017/02/05)
Given the high demand for green and sustainable synthetic methods for the formation of amides and peptidic bonds, herein we report the efficient, solvent-free mechanochemical synthesis of dipeptides from N-protected amino acids and amino acid methyl ester
A mild and efficient amide formation reaction mediated by P(OEt)3 and iodine
Chen, Pei-Jiang,Wang, Hai-Yang,Peng, Ai-Yun
, p. 94328 - 94331 (2015/11/17)
With the activation of P(OEt)3 and I2, carboxylic acids can smoothly react with various primary and secondary amines, affording a series of amides, including peptides without racemization. 31P NMR spectroscopy studies showed that carboxylic phosphoric mixed anhydride was the reactive intermediate and a possible mechanism was herein proposed.