4916-22-7

Basic information

• Product Name: 2-Butenoic acid, 3-(phenylamino)-, methyl ester, (2Z)-
• Synonyms: methyl (Z)-3-(phenylamino)but-2-enoate;3-phenylaminobut-2-enoic acid methyl ester;methyl 3-((Z)-phenylamino)-but-2-enoate;(Z)-3-(phenylamino)-but-2-enoic acid methylester;(Z)-3-Phenylamino-but-2-enoic acid methyl ester;methyl (Z)-3-(phenylamino)-2-butenoate;(Z)-methyl 3-(phenylamino)but-2-enoate
• CAS NO: 4916-22-7
• Molecular Formula: C11H13NO2
• Molecular Weight: 191.23
• Mol File: 4916-22-7.mol
• Article Data: 49

Chemical Properties

• Melting Point: 47 - 49 °C
• CAS DataBase Reference: 2-Butenoic acid, 3-(phenylamino)-, methyl ester, (2Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoic acid, 3-(phenylamino)-, methyl ester, (2Z)-(4916-22-7)
• EPA Substance Registry System: 2-Butenoic acid, 3-(phenylamino)-, methyl ester, (2Z)-(4916-22-7)

Safety Data

• Hazardous Substances Data: 4916-22-7(Hazardous Substances Data)

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 62-53-3 aniline 
• 23326-27-4 Methyl 2-butynoate 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 

Downstream Products

• 1888-01-3 3-ethyl-2-methylquinolin-4-ol 
• 5452-51-7 2,6-Dimethyl-1-phenyl-4-pyridon-3-carbonsaeure 
• 100749-52-8 4-(2-Methyl-chinolyl)essigsaeuremethylester-iodid 
• 1572039-09-8 C₁₈H₁₅ClN₂O₂ 
• 591741-72-9 methyl 5-methyl-1,2-diphenyl-1H-imidazole-4-carboxylate 
• 68870-58-6 methyl 3-(p-chlorophenyl)-5-methylisoxazole-4-carboxylate 
• 68870-53-1 methyl 4-methyl-1-phenyl-1H-1,2,3-triazole-5-carboxylate 

Relevant articles and documents

Facile one-pot multicomponent synthesis of highly functionalized tetrahydropyridines using thiamine hydrochloride as an organocatalyst

Thiamine hydrochloride (VitB1) has been found to be an efficient catalyst for the multicomponent synthesis of highly functionalized tetrahydropyridines from the reaction of β-ketoester, aromatic aldehydes and anilines. VitB1 is easily available, cheap, and eco benign.

Multicomponent reaction for the synthesis of highly functionalized piperidine scaffolds catalyzed by TMSI

An efficient method for the synthesis of highly functionalized piperidines via one-pot domino reaction of β-ketoesters, aromatic aldehydes, and aromatic amines was reported. This multicomponent coupling was catalyzed by TMSI in methanol at room temperature, giving desired substituted pyridines in moderate to good yields.

A simple route towards the synthesis of 1,4,5-trisubstituted 1,2,3-triazoles from primary amines and 1,3-dicarbonyl compounds under metal-free conditions

An acetic acid-promoted approach that enables the synthesis of 1,4,5-trisubstituted 1,2,3-triazole derivatives has been achieved. This transformation employs readily available primary amines, 1,3-dicarbonyls and tosyl azide as the starting materials via a