68870-53-1

Basic information

• Product Name: methyl 4-methyl-1-phenyl-1H-1,2,3-triazole-5-carboxylate
• Synonyms: methyl 4-methyl-1-phenyl-1H-1,2,3-triazole-5-carboxylate
• CAS NO: 68870-53-1
• Molecular Weight: 217.227
• Mol File: 68870-53-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 4-methyl-1-phenyl-1H-1,2,3-triazole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-methyl-1-phenyl-1H-1,2,3-triazole-5-carboxylate(68870-53-1)
• EPA Substance Registry System: methyl 4-methyl-1-phenyl-1H-1,2,3-triazole-5-carboxylate(68870-53-1)

Safety Data

• Hazardous Substances Data: 68870-53-1(Hazardous Substances Data)

Upstream product

• 4916-22-7 methyl 3-phenylaminobut-2-enoate 
• 62-53-3 aniline 
• 105-45-3 acetoacetic acid methyl ester 

Relevant articles and documents

TBAI or KI-Promoted Oxidative Coupling of Enamines and N-Tosylhydrazine: An Unconventional Method toward 1,5- and 1,4,5-Substituted 1,2,3-Triazoles

A novel method for the synthesis of 1,5- and 1,4,5-substituted 1,2,3-triazoles has been reported. This approach is promoted by iodine-TBHP oxidation system using enamines and N-tosylhydrazine as materials, which avoid the dependence of traditional methods on azides and transition metals. Through this approach, various 1,5- and 1,4,5-substituted 1,2,3-triazoles were delivered in moderate to high yields. The mechanistic study indicated that an amino exchange would be involved in the reaction process. Moreover, the product methyl 1-(2-methoxyphenyl)-4-methyl-1H-1,2,3-triazole-5-carboxylate is a useful precursor to anti-influenza A agent, and further application research was conducted. (Figure presented.).