493036-26-3

Basic information

• Product Name: Benzoic acid, 4-[2-[(5R)-2-oxo-5-[(phenylmethoxy)methyl]-1-pyrrolidinyl]ethyl]-, ethyl ester
• CAS NO: 493036-26-3
• Molecular Formula: C23H27NO4
• Molecular Weight: 381.472
• Mol File: 493036-26-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[2-[(5R)-2-oxo-5-[(phenylmethoxy)methyl]-1-pyrrolidinyl]ethyl]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[2-[(5R)-2-oxo-5-[(phenylmethoxy)methyl]-1-pyrrolidinyl]ethyl]-, ethyl ester(493036-26-3)
• EPA Substance Registry System: Benzoic acid, 4-[2-[(5R)-2-oxo-5-[(phenylmethoxy)methyl]-1-pyrrolidinyl]ethyl]-, ethyl ester(493036-26-3)

Safety Data

• Hazardous Substances Data: 493036-26-3(Hazardous Substances Data)

Upstream product

• 77266-69-4 2-(4-carboethoxyphenyl)ethylamine 
• 74003-31-9 4-bromoethylbenzoic acid ethyl ester 
• 493036-25-2 4-[2-((S)-5-Benzyloxy-4-hydroxy-pentanoylamino)-ethyl]-benzoic acid ethyl ester 
• 100-39-0 benzyl bromide 
• 52062-92-7 4-(2-bromoethyl)benzoic acid 
• 32780-06-6 (5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran 
• 32780-08-8 (5S)-5-[(benzyloxy)methyl]dihydrofuran-2(3H)-one 

Downstream Products

• 493036-27-4 (R)-N'-[2-(4-carboethoxyphenyl)ethyl]-5-hydroxymethyl-2-pyrrolidinone 
• 819067-23-7 4-{2-[(R)-2-Oxo-5-((E)-3-oxo-oct-1-enyl)-pyrrolidin-1-yl]-ethyl}-benzoic acid ethyl ester 
• 493036-24-1 AS₇₀₁₆₆₆ 
• 493036-28-5 4-{2-[(R)-2-((E)-(S)-3-Hydroxy-oct-1-enyl)-5-oxo-pyrrolidin-1-yl]-ethyl}-benzoic acid ethyl ester 

Relevant articles and documents

Lactams as EP4 prostanoid receptor agonists. 3. Discovery of N-ethylbenzoic acid 2-pyrrolidinones as subtype selective agents

Two distinct synthetic schemes were applied to access heteroatom-containing α-chain lactams or lactams terminated as aryl acids. The latter lactams were devised using a pharmacophore for EP4 receptor activity. γ-Lactams were characterized for their prostanoid EP receptor affinities and EP 4 activity and found to be selective for the EP2 and EP4 receptors or selective for the EP4 subtype. Benzoic acid 17 displayed enhanced in vivo exposure relative to 3.