52062-92-7

Basic information

• Product Name: 4-(2-BROMOETHYL)BENZOIC ACID
• Synonyms: Benzoic acid, 4-(2-bromoethyl)-;4-(2-BROMOETHYL)BENZOIC ACID;P-(B-BROMOETHYL)BENZOIC ACID;P(BETA-BROMOETHYL)BENZOIC ACID;Bromoethylbenzoicacid;4-(2-BROMOETHYL)BENZOIC ACID 97%;Einecs 257-632-7;4-(BroMoethyl)benzoic acid
• CAS NO: 52062-92-7
• Molecular Formula: C₉H₉BrO₂
• Molecular Weight: 229.07
• EINECS: 257-632-7
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 52062-92-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 206-208°C
• Boiling Point: 332.5 °C at 760 mmHg
• Flash Point: 154.9 °C
• Appearance: /
• Density: 1.548g/cm³
• Vapor Pressure: 5.79E-05mmHg at 25°C
• Refractive Index: 1.597
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.24±0.10(Predicted)
• CAS DataBase Reference: 4-(2-BROMOETHYL)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-BROMOETHYL)BENZOIC ACID(52062-92-7)
• EPA Substance Registry System: 4-(2-BROMOETHYL)BENZOIC ACID(52062-92-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 52062-92-7(Hazardous Substances Data)

Usage

Uses

4-(2-Bromoethyl)benzoic Acid is a reagent in the synthesis of 5-thia-2,6-diamino-4(3H)-oxopyrimidine as potent inhibitors of glycinamide ribonucleotide transformylase (GART). Also, it is a reagent in the synthesize pyrrole[3,2-d]pyrimidine folate analogs, as potential anticancer agents.

InChI:InChI=1/C9H9BrO2/c10-6-5-7-1-3-8(4-2-7)9(11)12/h1-4H,5-6H2,(H,11,12)

Upstream product

• 40422-73-9 1-[4-(2-bromoethyl)phenyl]ethanone 
• 7617-70-1 4-(2-Bromoethyl)benzaldehyde 
• 103-63-9 1-phenyl-2-bromoethane 

Downstream Products

• 74003-31-9 4-bromoethylbenzoic acid ethyl ester 
• 55584-01-5 4-(2-cyanoethyl)benzoic acid 
• 149325-41-7 tert-Butyl 4-(2-bromoethyl)benzoate 
• 136333-97-6 methyl 4-(2-bromoethyl)benzoate 
• 193964-24-8 methyl 4-[2-(1-pyrrolidinyl)ethyl]benzoate 
• 77266-69-4 2-(4-carboethoxyphenyl)ethylamine 
• 493036-27-4 (R)-N'-[2-(4-carboethoxyphenyl)ethyl]-5-hydroxymethyl-2-pyrrolidinone 
• 493036-26-3 (R)-N'-[2-(4-carboethoxyphenyl)ethyl]-5-benzyloxymethyl-2-pyrrolidinone 
• 493036-25-2 4-[2-((S)-5-Benzyloxy-4-hydroxy-pentanoylamino)-ethyl]-benzoic acid ethyl ester 
• 819067-23-7 4-{2-[(R)-2-Oxo-5-((E)-3-oxo-oct-1-enyl)-pyrrolidin-1-yl]-ethyl}-benzoic acid ethyl ester 
• 493036-24-1 AS₇₀₁₆₆₆ 
• 493036-28-5 4-{2-[(R)-2-((E)-(S)-3-Hydroxy-oct-1-enyl)-5-oxo-pyrrolidin-1-yl]-ethyl}-benzoic acid ethyl ester 
• 193960-65-5 (2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl)-(4-[2-(1-pyrrolidinyl)ethyl]phenyl)ketone 
• 155172-15-9 4-(2-mercaptopropyl)benzoic acid methyl ester 

Relevant articles and documents

DRUG ACTIVE IN NEUROPATHIC PAIN

The present invention relates to a compound of formula (I): in which: R is a linear or branched alkyl group containing between 1 and 3 carbon atoms, Y is CH or N, and p is an integer between 0 and 3 and preferably 0 and 1, and salts thereof, either acid-addition salts with a pharmaceutically acceptable organic or mineral acid, or base-addition salts with a pharmaceutically acceptable organic or mineral base. The invention also relates to a process for preparing the compound of formula (I), and to a pharmaceutical composition comprising it. The invention also relates to the use of an indazole for preparing a pharmaceutical composition that is active in the treatment of neuropathic pain.

Antihypertensive dihydropyridine compositions, optical isomers and intermediates

Compositions containing dihydropyridine derivatives which are useful for treating congestive heart failure, hypertension, or angina have the formula: STR1 or a pharmaceutically acceptable acid addition salt thereof, wherein n is an integer from 0 to 8; Y is --O--, --NH--, --NR2 --, --S--, --S(O)--, --S(O)2 --, or a bond; R1 and R2 are each independently A1, A2, A3 or A4 where A1 is --(CH2)m (CHOH)p CH2 OH; A2 is --(CH2)q CH(3-r) [(CH2)s OH]r ; A3 is --(CH2)q CH(3-r) [(CH2)p COOR3 ]r ; and A4 is --(CH2)m COOR3 ; where m is an integer from 1 to 8; p is an integer from 0 to 4; q is an integer from 0 to 8; r is 2 or 3; s is an integer from 1 to 4; and R3 is H or alkyl of 1 to 18 carbon atoms; R4 is --NO2, --CF3, or halo; and R5 is lower alkyl or --CH2 CH2 OCH3. Also disclosed are optical isomers of the above compounds, as well as intermediates in the preparation of these final products.