4974-59-8

Basic information

• Product Name: Ethanone, 2,2-dichloro-1-(4-methylphenyl)- (9CI)
• Synonyms: Ethanone, 2,2-dichloro-1-(4-methylphenyl)- (9CI);2,2-Dichloro-1-(4-methylphenyl)ethanone;2,2-Dichloro-4'-methylacetophenone;2,2-Dichloro-1-(p-tolyl)ethanone
• CAS NO: 4974-59-8
• Molecular Formula: C₉H₈Cl₂O
• Molecular Weight: 203.06522
• Product Categories: ACETYLHALIDE
• Mol File: 4974-59-8.mol
• Article Data: 36

Chemical Properties

• Melting Point: 54-56℃
• Boiling Point: 278℃
• Flash Point: 116℃
• Appearance: /
• Density: 1.266
• Vapor Pressure: 0.00445mmHg at 25°C
• Refractive Index: 1.545
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Ethanone, 2,2-dichloro-1-(4-methylphenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2,2-dichloro-1-(4-methylphenyl)- (9CI)(4974-59-8)
• EPA Substance Registry System: Ethanone, 2,2-dichloro-1-(4-methylphenyl)- (9CI)(4974-59-8)

Safety Data

• Hazardous Substances Data: 4974-59-8(Hazardous Substances Data)

Usage

General Description

Ethanone, 2,2-dichloro-1-(4-methylphenyl)- (9CI) is a particular chemical compound with the molecular formula C9H8Cl2O. It is a member of the ketone family and contains two chlorine atoms, a methylphenyl group, and a carbonyl group. This chemical is not commonly found in nature and is typically manufactured for use in various applications, including as an intermediate in the production of pharmaceuticals and agrochemicals. It is important to handle this compound with caution and follow safety protocols, as it may pose health and environmental risks if not used properly.

InChI:InChI=1/C9H8Cl2O/c1-6-2-4-7(5-3-6)8(12)9(10)11/h2-5,9H,1H3

Upstream product

• 79-36-7 dichloroacethyl chloride 
• 108-88-3 toluene 
• 67-56-1 methanol 
• 36930-95-7 2,2,2-trichloro-1-(4-methylphenyl)ethanone 
• 64-19-7 acetic acid 
• 766-97-2 4-n-methylphenylacetylene 
• 122-00-9 para-methylacetophenone 
• 536-50-5 CH₃C₆H₄CH(CH₃)OH 
• 100-58-3 phenylmagnesium bromide 
• 16002-63-4 phenylmagnesium iodide 
• 122-04-3 4-nitro-benzoyl chloride 
• 18103-98-5 3-dimethylamino-1-(4-methyl-phenyl)-2-propen-1-one 
• 670229-04-6 3-(4-methylphenyl)-3-oxopropanamide 
• 99-94-5 p-Toluic acid 

Downstream Products

• 5162-82-3 3-chloro-4-methylbenzoic acid 
• 73805-19-3 trans-β-chloro-p-methylstyrene oxide 
• 5436-83-9 N-benzyl-4-methylbenzamide 
• 13143-43-6 1-(4-phenylmethyl)-3-(4-methylphenyl)urea 
• 22693-32-9 4-methylbenzoyl azide 
• 54149-77-8 1,1-dimethoxy-2-(4-methylphenyl)-ethan-2-one 
• 54149-78-9 2,2-diethoxy-1-(p-tolyl)ethan-1-one 
• 67656-60-4 2,2-dichloro-1-(4-methylphenyl)ethenyl diethyl phosphate 
• 710311-29-8 4-methyl-N-(2-methylquinolin-4-yl)benzamide 
• 86329-49-9 anti-p-tolylglyoxime 
• 24314-35-0 1,4-bis(4-chlorophenyl)butane-1,4-dione 
• 120312-68-7 1-(4'-chlorophenyl)-4-(4''-methylphenyl)-butane-1,4-dione 
• 13145-56-7 1,4-bis(4-tolyl)butane-1,4-dione 
• 7163-50-0 (4-methylphenyl)(oxo)acetic acid 

Relevant articles and documents

Access to α,α-dihaloacetophenones through anodic C[dbnd]C bond cleavage in enaminones

We have developed a method to synthesize α,α-dihaloketones under electrochemical conditions. In this reaction, the Cl- or Br- is oxidized to Cl2 or Br2 at the anode, which undergoes two-step addition reactions with the N,N-dimethyl enaminone, and finally breaks C[dbnd]C of the N,N-dimethyl enaminone to generate α,α-dihaloketones. The electrosynthesis reaction can be conveniently carried out in an undivided electrolytic cell at room temperature. In addition, various functional groups are compatible with this green protocol which can be applied simultaneously to the gram scale without significantly lower yield.

Solvent-free preparation of α,α-dichloroketones with sulfuryl chloride

An efficient and facile method is reported for the synthesis of a series of α,α-dichloroketones. The direct dichlorination of methyl ketones and 1,3-dicarbonyls using an excess amount of sulfuryl chloride affords the corresponding gem-dichloro compounds in moderate to excellent yields. Moreover, the protocol features high yields, broad substrate scope, and simple reaction conditions without using any catalysts and solvents.

Electrochemical synthesis of α,α-dihaloacetophenones from terminal alkyne derivatives

By virtue of electrochemistry, a series of α,α-dihaloacetophenones were easily obtained with good to excellent yields. This electrochemical procedure was taken in a divided cell with constant current in aqueous media. The reaction can be carried out smoothly at room temperature under metal and oxidant free condition, which provides an eco-friendly synthesis for the α,α-dihaloacetophenone derivatives.