5005-40-3

Basic information

• Product Name: phenyl(pyridin-3-yl)acetonitrile
• CAS NO: 5005-40-3
• Molecular Formula: C₁₃H₁₀N₂
• Molecular Weight: 194.2319
• Mol File: 5005-40-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 344.9°C at 760 mmHg
• Flash Point: 120.7°C
• Density: 1.124g/cm³
• Vapor Pressure: 6.39E-05mmHg at 25°C
• Refractive Index: 1.589
• CAS DataBase Reference: phenyl(pyridin-3-yl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl(pyridin-3-yl)acetonitrile(5005-40-3)
• EPA Substance Registry System: phenyl(pyridin-3-yl)acetonitrile(5005-40-3)

Safety Data

• Hazardous Substances Data: 5005-40-3(Hazardous Substances Data)

Usage

General Description

Phenyl(pyridin-3-yl)acetonitrile, also known as 3-(phenylamino)pyridine-4-carbonitrile, is a chemical compound with the molecular formula C13H10N2. It is a heterocyclic aromatic compound containing a phenyl group and a pyridine ring, with a nitrile functional group attached to the carbon atom of the pyridine ring. phenyl(pyridin-3-yl)acetonitrile is used as a building block in organic synthesis and pharmaceutical research, and it has potential applications in the development of new drugs and agrochemicals. It is also used as an intermediate in the production of various fine chemicals and dyes. Phenyl(pyridin-3-yl)acetonitrile is a solid at room temperature and is not highly soluble in water, but it is soluble in organic solvents such as acetone and ethyl acetate.

Upstream product

• 140-29-4 phenylacetonitrile 
• 626-60-8 3-Chloropyridine 
• 6270-47-9 1-phenyl-1-(pyrid-3-yl)methanol 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 626-55-1 3-Bromopyridine 
• 372-47-4 3-Fluoropyridine 

Downstream Products

• 5424-19-1 3-Benzoylpyridine 
• 21883-33-0 phenyl-pyridin-3-yl-acetic acid 
• 308806-04-4 2-phenyl-2-(pyrid-3-yl)ethylamine methyl carbamate 

Relevant articles and documents

INHIBITORS OF HISTONE DEACETYLASE

This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula compounds of the Formula (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein groups L, M, X and Y are as defined herein.

Anti-viral method

PCT No. PCT/US97/07431 Sec. 371 Date Jan. 6, 1999 Sec. 102(e) Date Jan. 6, 1999 PCT Filed May 2, 1997 PCT Pub. No. WO97/41846 PCT Pub. Date Nov. 13, 1997The present invention provides compounds which inhibit an envelope virus by inhibiting the fusion of the virus with the host cell. The virus may be inhibited in an infected cell, a cell susceptible of infection or a mammal in need thereof.

REACTIONS OF β-BROMO-N-HETEROAROMATICS WITH PHENYLACETONITRILE

The reaction of 3-bromopyridine with phenylacetonitrile in the presence of NaH in THF gave a simple substitution product, α-phenyl-3-pyridineacetonitrile, whereas the reaction of 5-bromopyrimidine with phenylacetonitrile under similar conditions gave a ring-transformation product, 2-amino-5-bromo-3-phenylpyridine. 3-Bromoquinoline and 4-bromoisoquinoline underwent the former type reaction, while 3-bromo- and 3-chloroisoquinolines were converted into 2-amino-3-phenyl-1-naphthalenecarbonitrile according to the latter type reaction.