502442-61-7

Basic information

• Product Name: ethyl (4R)-2-(N-tert-butyloxycarbonylamino)-4-tert-butyldiphenylsiloxy-5-hydroxy-2-pentenoate
• Synonyms: ethyl (4R)-2-(N-tert-butyloxycarbonylamino)-4-tert-butyldiphenylsiloxy-5-hydroxy-2-pentenoate
• CAS NO: 502442-61-7
• Molecular Weight: 513.706
• Mol File: 502442-61-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl (4R)-2-(N-tert-butyloxycarbonylamino)-4-tert-butyldiphenylsiloxy-5-hydroxy-2-pentenoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (4R)-2-(N-tert-butyloxycarbonylamino)-4-tert-butyldiphenylsiloxy-5-hydroxy-2-pentenoate(502442-61-7)
• EPA Substance Registry System: ethyl (4R)-2-(N-tert-butyloxycarbonylamino)-4-tert-butyldiphenylsiloxy-5-hydroxy-2-pentenoate(502442-61-7)

Safety Data

• Hazardous Substances Data: 502442-61-7(Hazardous Substances Data)

Upstream product

• 502442-57-1 ethyl (4R)-2-(N-tert-butyloxycarbonylamino)-5-tert-butyldimethylsiloxy-2-pentenoate 
• 502442-54-8 ethyl (4R)-2-(N-tert-butyloxycarbonylamino)-4,5-dihydroxy-2-pentenoa 
• 295365-33-2 ethyl tert-butoxycarbonylamino(toluene-4-sulfonyl)acetate 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 502442-59-3 ethyl (4R)-2-(N-tert-butyloxycarbonylamino)-5-tert-butyldimethylsiloxy-4-tert-butyldiphenylsiloxy-2-pentenoate 

Downstream Products

• 502442-65-1 ethyl (2R,4R)-N-tert-butyloxycarbonyl-4-tert-butyldiphenylsiloxyprolinate 
• 135042-12-5 (4R)-1-(tert-butoxycarbonyl)-4-hydroxy-D-proline 
• 502442-63-9 ethyl (4R)-N-tert-butyloxycarbonyl-4-tert-butyldiphenylsiloxy-α,β-didehydroprolinate 

Relevant articles and documents

A new synthetic method for the preparation of α,β-didehydroamino acid derivatives by means of a wittig-type reaction. Syntheses of (2S, 4S)- and (2R, 4R)-4-hydroxyprolines

Ethyl N-Boc- and N-Z-α-tosylglycinates were reacted with a variety of aldehydes in the presence of tributylphosphine and a base to afford the corresponding α,β-didehydroamino acid derivatives with high (Z)-selectivity in good yields. Moreover, ethyl (4S)- and (4R)-2-(N-Boc-amino)-4,5-isopropylidenedioxy-2-pentenoates prepared by the present method were converted to (2S, 4S)- and (2R, 4R)-4-hydroxyprolines, respectively.