5055-74-3

Basic information

• Product Name: 1,5-Diphenyl-1H-1,2,4-triazole-3(2H)-thione
• Synonyms: 1,5-Diphenyl-1H-1,2,4-triazole-3(2H)-thione
• CAS NO: 5055-74-3
• Molecular Formula: C₁₄H₁₁N₃S
• Molecular Weight: 253.32224
• Mol File: 5055-74-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 188 °C
• Boiling Point: 367.9±25.0 °C(Predicted)
• Appearance: /
• Density: 1.25±0.1 g/cm3(Predicted)
• PKA: 5.92±0.20(Predicted)
• CAS DataBase Reference: 1,5-Diphenyl-1H-1,2,4-triazole-3(2H)-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-Diphenyl-1H-1,2,4-triazole-3(2H)-thione(5055-74-3)
• EPA Substance Registry System: 1,5-Diphenyl-1H-1,2,4-triazole-3(2H)-thione(5055-74-3)

Safety Data

• Hazardous Substances Data: 5055-74-3(Hazardous Substances Data)

Usage

General Description

1,5-Diphenyl-1H-1,2,4-triazole-3(2H)-thione is an organic compound that is also known as DPTH. It is a heterocyclic compound containing a five-membered ring with nitrogen and sulfur atoms. DPTH has multiple potential applications, including as a pesticide, a fungicide, and a photoinitiator in the manufacturing of polymers. It is also used in the production of pharmaceuticals and as an intermediate in organic synthesis. DPTH has been found to exhibit antimicrobial, anticancer, and antiviral properties, making it a target for research in the development of new drugs and treatments. However, it is important to handle and use DPTH with caution, as it may have harmful effects on human health and the environment.

Upstream product

• 100-63-0 phenylhydrazine 
• 532-55-8 Benzoyl isothiocyanate 
• 645-48-7 1-phenyl-3-thiosemicarbazide 
• 59-88-1 phenylhydrazine hydrochloride 
• 71141-24-7 1-benzoyl-1-phenyl thiosemicarbazide 
• 1147550-11-5 ammonium thiocyanate 
• 98-88-4 benzoyl chloride 
• 6287-87-2 benzoyldithiocarbamic acid ethyl ester 
• 4513-25-1 N-Benzensulfonyl-benzimidchlorid 
• 837-18-3 N-benzylbenzenesulfonamide 
• 74439-48-8 N-Benzensulfonyl-benzimidoyl-isothiocyanat 
• 20800-27-5 N-Phenyl-benzimidoyl-isothiocyanat 
• 24786-17-2 N-benzoyl-S-benzyldithiocarbamate 
• 100-52-7 benzaldehyde 

Downstream Products

• 72234-23-2 1,5-diphenyl-3-methylthio-1,2,4-triazole 
• 99793-67-6 1,5-diphenyl-3-<(tetrafluoroethyl)thio>-1H-1,2,4-triazole 

Relevant articles and documents

Synthesis and antitumor effects of a new class of 1,2,4-triazole derivatives

In order to obtain more effective antitumor agents, a new class of 1,2,4-triazole derivatives bearing disulfide bond were designed and synthesized. All the final compounds were confirmed by IR, 1H NMR, 13C NMR and HR-ESI-MS. The in vitro cytotoxicity of the compounds on the SMMC-7721, Hela, A549 cancer cell lines and the L929 normal cell lines were assessed by cell counting kit-8 (CCK-8). Many of tested compounds 8a–h, 9a–h, 10a–h had better cytotoxic activity on various cancer cell lines than positive control 5-fluorouracil, and they were less cytotoxic to normal cell line L929 than cancer cells. Among them, compounds 9e, 9g, and 10h showed better cytotoxic activity on SMMC-7721 cells with IC50 values 4.12, 2.92, and 4.53 μM, respectively. Compounds 8a, 9g, 10g and 10h displayed high antiproliferative activity against Hela cells with IC50 values 6.31, 4.31, 6.31 and 3.97 μM, respectively. Compounds 8c, 10a and 10h revealed effective biological potency on A549 cells with IC50 values 4.75, 4.92 and 3.73 μM, respectively. Moreover, a great majority of tested compounds revealed low cytotoxicity on normal cell line L929.

Synthesis and antitumor activity evaluation of some novel pyrazolotriazine derivatives

6-Aminopyrazolo[1,2-a][1,2,4]triazine-4,8-dione derivative 3 was obtained upon the reaction of the acid hydrazide derivative 2a with ethyl cyanoacetate. The reactions of 3 with several electrophiles such as aldehydes, isatin, acetic anhydride, phenyl isoc

STRUCTURE INVESTIGATIONS ON SOME DIPHENYLTRIAZOLES

Syntheses of 1,3-diphenyl-4H-1,2,4-triazolin-5-thione (1) and 1,5-diphenyl-2H-1,2,4-triazolin-3-thione (2) have been reinvestigated and the structures proposed in the literature corrected. 1H-NMR, 13C-NMR, UV and MS studies of these compounds and their S-