5060-53-7

Basic information

• Product Name: 4(3H)-Quinazolinone, 8-hydroxy-2-methyl-3-(2-methylphenyl)-
• Synonyms: 4(3H)-Quinazolinone, 8-hydroxy-2-methyl-3-(2-methylphenyl)-
• CAS NO: 5060-53-7
• Molecular Formula: C₁₆H₁₄N₂O₂
• Molecular Weight: 266.29
• Mol File: 5060-53-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4(3H)-Quinazolinone, 8-hydroxy-2-methyl-3-(2-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(3H)-Quinazolinone, 8-hydroxy-2-methyl-3-(2-methylphenyl)-(5060-53-7)
• EPA Substance Registry System: 4(3H)-Quinazolinone, 8-hydroxy-2-methyl-3-(2-methylphenyl)-(5060-53-7)

Safety Data

• Hazardous Substances Data: 5060-53-7(Hazardous Substances Data)

Upstream product

• 548-93-6 3-hydroxyanthranilic acid 
• 1319735-56-2 8-acetyloxy-2-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone 

Downstream Products

• 1319735-76-6 ethyl 2-[3,4-dihydro-2-methyl-3-(2-methylphenyl)-4-oxoquinazolin-8-yloxy]acetate 
• 1353155-45-9 2-(2-methyl-4-oxo-3-o-tolyl-3,4-dihydroquinazolin-8-yloxy)-N-(4-oxo-2-phenylthiazolidin-3-yl)acetamide 
• 1353155-48-2 N-(1,3-dioxoisoindolin-2-yl)-[2-(2-methyl)-3-(2-methylphenyl)-4(3H)-quinazolin-8-yloxy]acetamide 
• 1353155-51-7 [2-(2-methyl)-3-(2-methylphenyl)-4(3H)-quinazolin-8-yloxy-N-(4,5,6,7-tetrabromo-1,3-dioxoisoindolin-2-yl)]acetamide 
• 1353155-54-0 [2-(2-methyl)-3-(2-methylphenyl)-4(3H)-quinazolin-8-yloxy]-N-(4,5,6,7-tetrachloro-1,3-dioxoisoindolin-2-yl)acetamide 
• 1353155-58-4 ethyl 2-[2-(2-methyl)-3-(2-methylphenyl)-4(3H)-(quinazolin-8-yloxy)acetyl]hydrazinecarboxylate 
• 1353155-62-0 4-[(2-methyl)-3-(2-methylphenyl)-4(3H)-quinazolin-8-yloxy]pyrazolidin-3,5-dione 
• 1353155-17-5 2-[(2-(2-methyl-3-(2-methylphenyl)-4(3H)-quinazolin-8-yloxy)acetyl)]hydrazincarboxamide 
• 1353155-66-4 N’-(hydrazinecarbonyl)-2-[(2-methyl-3-(2-methylphenyl)-4(3H)-quinazolin-8-yloxy)]acetohydrazide 
• 1365839-62-8 potassium 2-[2-(2-methyl-3-(2-methylphenyl)-4(3H)-quinazolin-8-yloxy)acetyl]hydrazinecarbodithioate 
• 1353155-70-0 methyl 2-[2-(2-methyl-3-(2-methylphenyl)-4(3H)-quinazolin-8-yloxy)acetyl] hydrazinecarbodithioate 
• 1353155-74-4 methyl 8-[(5-mercapto-1,3,4-thiadiazol-2-yl)methoxy]-2-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone 
• 1353155-78-8 8-(5-mercapto-1,3,4-oxadiazol-2-yl)methoxy-[2-methyl-3-(2-methylphenyl)]-4(3H)-quinazolinone 
• 1353155-84-6 8-(4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)methoxy-[2-methyl-3-(2-methyl-phenyl)]-4(3H)-quinazolinone 

Relevant articles and documents

Design and evaluation of new hybrid pharmacophore quinazolino-tetrazoles as anticonvulsant strategy

The anticonvulsant study of 25 newly synthesized quinazolin-4(3H)-one substituted 1H and 2H-tetrazoles (6a-6d, 7a-7b, 8a-8i, 8a′-8i′) was executed. The study employing the maximal electroshock and subcutaneous pentylenetetrazole (scPTZ) screens, the 'gold standards' in the preliminary anticonvulsant breakthrough and the neurotoxicity study applying the rotorod test unveiled a triad of compounds 6c, 7b and 8i′ as the looms amongst the compendium of synthesized compounds. The quantification data of these compounds following oral administration in rats showcased 7b to endorse a remarkable position in the MES screen with a protective indice (PI) of >39.67 and 6c in the scPTZ delineating a PI > 3.10, respectively. All the potent compounds were destitute of toxicity.

On the biotransformation of 2-methyl-3-o-tolyl-4(3H)-quinazolinone (Methaqualone). 2. On the structure and synthesis of some renal excretory products

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