50603-96-8

Basic information

• Product Name: 3-(4-bromophenyl)-5-phenyl-1H-pyrazole
• Synonyms: 3-(4-bromophenyl)-5-phenyl-1H-pyrazole
• CAS NO: 50603-96-8
• Molecular Weight: 299.17
• Mol File: 50603-96-8.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 3-(4-bromophenyl)-5-phenyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-bromophenyl)-5-phenyl-1H-pyrazole(50603-96-8)
• EPA Substance Registry System: 3-(4-bromophenyl)-5-phenyl-1H-pyrazole(50603-96-8)

Safety Data

• Hazardous Substances Data: 50603-96-8(Hazardous Substances Data)

Usage

Chemical structure

pyrazole derivative with a bromine-substituted phenyl ring at the 3-position and a phenyl ring at the 5-position

Biological activities

anti-inflammatory, analgesic, antipyretic

Potential applications

treating inflammatory and pain-related conditions, antimicrobial agent, anticancer agent

Ongoing research

synthesis, properties, potential applications in medicinal chemistry

Upstream product

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• 142739-40-0 1-(4-bromo-phenyl)-3-phenyl-prop-2-yn-1-ol 
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Relevant articles and documents

One-pot regioselective synthesis of substituted pyrazoles and isoxazoles in PEG-400/water medium by Cu-free nano-Pd catalyzed sequential acyl Sonogashira coupling-intramolecular cyclization

Catalyst efficacy of in situ generated Pd-nanoparticles (PdNPs) in the regioselective one-pot synthesis of 3,5-di & 3,4,5-trisubstituted pyrazoles and 3,5-disubstituted isoxazoles in environmentally benign PEG-400/H2O medium, which involves the sequential (i) Cu-free acyl-Sonogashira coupling (ASC) and (ii) intramolecular ynone-amine cyclization under PTC conditions was described. The results of controlled experiments support the operation of two sequential catalytic cycles (ASC/cyclization) and achievement of complementary/opposite regioselectivity via ynone-bound palladium in a one-pot approach. Moreover, the in situ PdNPs recovered after the first catalytic cycle of the one-pot reaction sequence have been reused again five times successively. Besides, prior to the above studies, the efficacy of some common Pd-N-heterocyclic carbene (Pd-NHC) complexes in catalyzing the same one-pot two-step reaction sequence (Cu-free ASC/cyclization) both in water and organic solvents was also optimized. In situ generation of PdNPs from above Pd-NHCs in water was also identified, but they are not reusable due to their large size distribution.

Transition Metal, Azide, and Oxidant-Free Homo- and Heterocoupling of Ambiphilic Tosylhydrazones to the Regioselective Triazoles and Pyrazoles

With N-tosylhydrazone as an ambiphilic reagent, an unprecedented cyclization reaction of two identical or different tosylhydrazones has been developed to access various 4,5-disubstituted-2H-triazoles under transition metal, azide, and oxidant-free conditi

Synthesis of 3,5-disubstituted-1H-pyrazoles from acid chlorides, alkynes, and hydrazine in the presence of silica-supported-zinc bromide

An efficient one-pot palladium- And copper-free procedure has been developed for a convenient synthesis of 3,5-disubstituted-1H-pyrazoles from various acid chlorides, terminal alkynes and hydrazine by a coupling reaction and cyclocondensation sequence. Acid chlorides react with terminal alkynes in the presence of silica-supported-zinc bromide to give α,β-unsaturated ynones, and in situ conversion into pyrazoles by the hydrazine cyclocondensation.