5063-96-7

Basic information

• Product Name: N-MALEIMIDOMETHANOL
• Synonyms: N-MALEIMIDOMETHANOL;N-Methylolmaleimide;1-(Hydroxymethyl)-1H-pyrrole-2,5-dione;1-Hydroxymethyl-1H-pyrrole-2,5-dione;2,5-Dioxo-2,5-dihydro-1H-pyrrole-1-methanol;MIRA-2;N-Hydroxymethylmaleimide;1H-Pyrrole-2,5-dione, 1-(hydroxymethyl)
• CAS NO: 5063-96-7
• Molecular Formula: C₅H₅NO₃
• Molecular Weight: 127.0981
• Product Categories: Maleimide Derivatives;MTS & Sulfhydryl Active Reagents
• Mol File: 5063-96-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 100-103°C
• Boiling Point: 279.8°Cat760mmHg
• Flash Point: 123°C
• Appearance: /
• Density: 1.501g/cm³
• Vapor Pressure: 0.000475mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 12.69±0.10(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: N-MALEIMIDOMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: N-MALEIMIDOMETHANOL(5063-96-7)
• EPA Substance Registry System: N-MALEIMIDOMETHANOL(5063-96-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 5063-96-7(Hazardous Substances Data)

Usage

Chemical Properties

White Crystalline Solid

Uses

Different sources of media describe the Uses of 5063-96-7 differently. You can refer to the following data:
1. A sulfhydryl reactive crosslinking reagent
2. A sulfhydryl reactive crosslinking reagent.

InChI:InChI=1/C5H5NO3/c7-3-6-4(8)1-2-5(6)9/h1-2,7H,3H2

Upstream product

• 541-59-3 maleiimide 
• 50-00-0 formaldehyd 

Downstream Products

• 15209-14-0 bis(maleimidomethyl) ether 
• 89003-76-9 N-<2-(morpholin-4-yl)methyl>maleimide 
• 99984-67-5 N-anilinomethyl-maleimide 
• 72835-26-8 (2,5-dioxopyrrol-1-yl)methylpropanoate 
• 58539-16-5 phenyl-carbamic acid maleimidomethyl ester 
• 72835-28-0 N-benzoyloxymethyl-maleimide 
• 7450-68-2 N-(Acetoxymethyl)-maleimid 

Relevant articles and documents

Simultaneous and visual detection of cysteamine based on Michael addition reaction with polydiacetylene liposomes

In this study, we report the fabrication of a highly sensitive colorimetric and fluorometric sensor comprising self-assembled polydiacetylene (PDA) liposomes for the measurement of cysteamine concentration. The N-maleimidomethanol (HM) moiety was used as the Michael addition acceptor, which reacts with the thiol groups in cysteamine to generate maleimide-thiol conjugation resulting in the conformational transition of the conjugated backbone. Furthermore, this chemosensor system displays a clear blue-to-red colorimetric transition in the presence of cysteamine among various biothiols with high selectivity and sensitivity owing to the structural specificity of cysteamine. The resulting PDA solutions were analyzed via FE-SEM, UV-vis, fluorescence and Raman spectroscopy, and chromoisomerism for naked-eye visualization. This chemosensor provides a convenient method for the detection of cysteamine in aqueous solution and in real samples. This journal is

Two alternative approaches to the Diels-Alder polymerization of tung oil

Novel linear and crosslinked polymers from non-modified and modified tung oil are reported. These materials are based on the exploitation of the Diels-Alder reaction using, on the one hand, the dienic character of the three conjugated double bonds of tung oil and their susceptibility to react with a dienophile, and, on the other hand, the bulk reaction of furfuryl amine at the ester moieties of tung oil to produce three fatty acid furan amides, still bearing the three conjugated double bonds, and their linear polymerization with bismaleimides. This journal is the Partner Organisations 2014.

Derivatives of naphthalene with comt inhibiting activity

Compounds of formula (I′), wherein A, R1 to R3 and t are as defined in the disclosure, exhibit COMT enzyme inhibiting activity so that they are useful as COMT inhibitors.