50681-25-9

Basic information

• Product Name: 4-Pyridazinecarboxylic acid
• Synonyms: 4-Pyridazinecarboxylicacid
• CAS NO: 50681-25-9
• Molecular Formula: C₅H₄N₂O₂
• Molecular Weight: 228.2863
• EINECS: 610-561-9
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Pyridazines;Building Blocks;Pyridazine;Chemical Synthesis;Heterocyclic Building Blocks;Pyridazine series
• Mol File: 50681-25-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 244℃ (dec.)
• Boiling Point: 404.2 °C at 760 mmHg
• Flash Point: 198.3 °C
• Appearance: of-white to brown powder
• Density: 1.403 g/cm³
• Vapor Pressure: 5.1E-06mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.18±0.10(Predicted)
• CAS DataBase Reference: 4-Pyridazinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyridazinecarboxylic acid(50681-25-9)
• EPA Substance Registry System: 4-Pyridazinecarboxylic acid(50681-25-9)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:
• Safety Statements: S26:; S37/39:
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 50681-25-9(Hazardous Substances Data)

Usage

Uses

4-Pyridazinecarboxylic Acid is the pyridazine analog of Nicotinic Acid (N429250). 4-Pyridazinecarboxylic Acid is a glutamate racemase inhibitor. It is also used in characterization study of nicotinic acid receptors in mouse macrophages

General Description

Surface electrochemical studies of 4-pyridazinecarboxylic acid adsorbed at Pt(111) surfaces by electron energy-loss and Auger spectroscopy has been reported.

InChI:InChI=1/C15H16O2/c1-15(16,12-7-4-3-5-8-12)13-9-6-10-14(11-13)17-2/h3-11,16H,1-2H3

Upstream product

• 59648-14-5 pyridazine-4,5-dicarboxylic acid 
• 289-80-5 1,2-diazine 
• 124-38-9 carbon dioxide 
• 1120-88-3 4-methylpyridazine 
• 16082-13-6 pyridazine-3,4-dicarboxylic acid diethyl ester 
• 129116-95-6 6-ethoxy-3,4-diethoxycarbonyl-1-methoxycarbonyl-1,4,5,6-tetrahydropyridazine 
• 129116-97-8 pyridazine-3,4-dicarboxylic acid 

Downstream Products

• 174812-94-3 5-(3-trifluoromethylbenzoyl)pyridazine-4-carboxylic acid 
• 303084-25-5 N-(2-hydroxy-1,1-dimethylethyl)-4-pyridazinecarboxamide 
• 169050-36-6 N-tert-butyl-4-pyridazinecarboxamide 
• 91396-94-0 N-benzyl-4-pyridazinecarboxamide 
• 1033828-37-3 N-(4-fluorophenyl)-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridazine-4-carboxamide 
• 1071782-92-7 pyridazine-4-carboxylic acid (3,5-dichloro-phenyl)-(2-methoxy-benzyl)-amide 
• 34231-77-1 methyl pyridazine-4-carboxylate 
• 50901-46-7 Methyl 4-pyridazinyl ketone 
• 124436-57-3 2,5-Dihydro-pyridazine-4-carboxylic acid methyl ester 

Relevant articles and documents

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Carboxylation of C-H bonds using N -heterocyclic carbene gold(I) complexes

A highly efficient [(NHC)AuI]-based (NHC = N-heterocyclic carbene) catalytic system for the carboxylation of aromatic and heteroaromatic C-H bonds was developed. The significant base strength of the Au-OH species is at the origin of the activation process and permits the facile functionalization of C-H bonds without the use of other organometallic reagents.

Pyridazinone derivatives and processes for preparing the same

Disclosed is a pyridazinone compound represented by the formula (I): STR1 wherein X represents hydrogen atom or the like; Y represents a single bonding arm, oxygen atom or sulfur atom; A represents a straight or branched alkylene group which may have a double bond; B represents carbonyl group or thiocarbonyl group; and R2 represents an alkyl group having 1 to 10 carbon atoms which may be substituted or the like; or B represents sulfonyl group; and R2 represents a lower alkenyl group or the like; R1 represents hydrogen atom or the like; R3 represents hydrogen atom or the like; R4 represents hydrogen atom or the like; and R5 represents hydrogen atom or the like, or a pharmaceutically acceptable salt thereof.