5072-26-4 Usage
Chemical Properties
White Crystalline Solid
Uses
Different sources of media describe the Uses of 5072-26-4 differently. You can refer to the following data:
1. A potent and specific inhibitor of alpha-glutamyl cysteine synthetase
2. Biological tool for depletion of glutathione.
3. DL-Buthionine-sulfoximine is suitable for use to:examine whether the inhibition of glutathione by BSO enhances the apoptotic effect of estrogen on antihormone-resistant human breast cancer cellsinvestigate the effect of BSO on development of bovine embryosinhibit GSH in several studiesinvestigate the effect of GSH synthesis on oocyte maturationIt may be used to inhibit GSH and evaluate the hepatotoxicity and nephrotoxicity of natural food colorants in the absence of GSH
Definition
ChEBI: A sulfoximide that is the sulfoximine derivative of an analogue of DL-methionine in which the S-methyl group is replaced by S-butyl.
General Description
DL-buthionine-SR-sulfoximine (BSO) is an amino acid analogue, which acts as an inhibitor of γ-glutamylcysteine synthetase. BSO increases the sensitivity of Trypanosoma cruzi to antiparasitic drugs, such as nifurtimox or benznidazole.
Biochem/physiol Actions
DL-Buthionine-sulfoximine inhibits the biosynthesis of Glutathione (GSH) in liver and other peripheral organs. It does not have any effect on GSH in the CNS. It augments the antiproliferative action of reactive oxygen species (e.g., hydrogen peroxide), and agents that indirectly cause accumulation of reactive oxygen species (e.g., 2-methoxyestradiol, which increases intracellular superoxide anion).
Check Digit Verification of cas no
The CAS Registry Mumber 5072-26-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,0,7 and 2 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 5072-26:
(6*5)+(5*0)+(4*7)+(3*2)+(2*2)+(1*6)=74
74 % 10 = 4
So 5072-26-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m1/s1
5072-26-4Relevant articles and documents
Methionine and buthionine sulfoximines: Syntheses under mild and safe imidation/oxidation conditions
Buglioni, Laura,Bizet, Vincent,Bolm, Carsten
supporting information, p. 2209 - 2213 (2014/07/21)
Methionine and buthionine sulfoximines (MSO and BSO) are non-natural amino acids known to inhibit the biosynthesis of glutathione (GSH). The current syntheses of these biologically active molecules involve harsh reaction conditions and the use of hazardou
