509093-74-7

Basic information

• Product Name: 1-(4-fluoro-3-nitrobenzyl)piperidine
• Synonyms: 1-(4-fluoro-3-nitrobenzyl)piperidine
• CAS NO: 509093-74-7
• Molecular Formula: C₁₂H₁₅FN₂O₂
• Molecular Weight: 238.26
• Mol File: 509093-74-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 346.64°C at 760 mmHg
• Flash Point: 163.442°C
• Appearance: /
• Density: 1.242g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.563
• Storage Temp.: 2-8°C
• PKA: 7.69±0.10(Predicted)
• CAS DataBase Reference: 1-(4-fluoro-3-nitrobenzyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluoro-3-nitrobenzyl)piperidine(509093-74-7)
• EPA Substance Registry System: 1-(4-fluoro-3-nitrobenzyl)piperidine(509093-74-7)

Safety Data

• Hazardous Substances Data: 509093-74-7(Hazardous Substances Data)

Usage

General Description

1-(4-fluoro-3-nitrobenzyl)piperidine is a chemical compound that consists of a piperidine ring with a 4-fluoro-3-nitrobenzyl group attached to it. 1-(4-fluoro-3-nitrobenzyl)piperidine is often used in medicinal and pharmaceutical research as a starting material for the synthesis of various pharmaceutical drugs and molecules. It has also been studied for its potential use as an antipsychotic and antidepressant. Additionally, its unique structure and properties make it a valuable tool in the development of new therapeutic agents. However, it is important to handle this compound with caution as it may have potential risks associated with its use.

InChI:InChI=1/C12H15FN2O2/c13-11-5-4-10(8-12(11)15(16)17)9-14-6-2-1-3-7-14/h4-5,8H,1-3,6-7,9H2

Upstream product

• 110-89-4 piperidine 
• 42564-51-2 4-fluoro-3-nitrobenzaldehyde 
• 20274-69-5 (4-fluoro-3-nitrophenyl)methanol 
• 453-71-4 3-nitro-4-fluorobenzoic acid 

Downstream Products

• 509093-96-3 (3-fluorophenyl)-(2-nitro-4-piperidin-1-ylmethylphenyl)-amine 
• 509093-93-0 N-[1-(cis-4-hydroxymethyl-cyclohexyl)-5-piperidin-1-yl-methyl-1H-benzoimidazol-2-yl]-3-nitrobenzamide 
• 509093-91-8 N-(1-((1s,4s)-4-(hydroxymethyl)cyclohexyl)-5-(piperidin-1-ylmethyl)-1H-benzo[d]imidazol-2-yl)-3-(trifluoromethyl)benzamide 
• 509093-77-0 N-(1-Phenyl-5-piperidin-1-ylmethyl-1H-benzoimidazol-2-yl)-3-nitro-benzamide 
• 509093-72-5 N-(1-phenyl-5-piperidin-1-ylmethyl-1H-benzoimidazol-2-yl)-3-trifluoromethylbenzamide 
• 509093-78-1 N-{1-[4-(2-Hydroxy-ethyl)-phenyl]-5-piperidin-1-ylmethyl-1H-benzoimidazol-2-yl}-3-trifluoromethylbenzamide 
• 509093-75-8 N₁-phenyl-4-piperidin-1-ylmethyl-benzene-1,2-diamine 
• 509093-76-9 1-phenyl-5-piperidin-1-ylmethyl-1H-benzoimidazol-2-ylamine 
• 509093-73-6 (2-Nitro-4-piperidin-1-ylmethyl-phenyl)phenyl-amine 

Relevant articles and documents

COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 POLYPEPTIDES

The present disclosure relates to bifunctional compounds, which find utility as modulators of Interleukin-1 Receptor-Associated Kinase 4 (IRAK-4); the target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hppel-Lindau, cereblon, ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

Benzimidazole derivatives

Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related conditions or disorders. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, immune response regulation and cell proliferation. The subject compounds are 2-amino-imidazole derivatives.