509093-76-9

Basic information

• Product Name: 1H-Benzimidazol-2-amine, 1-phenyl-5-(1-piperidinylmethyl)-
• CAS NO: 509093-76-9
• Molecular Formula: C19H22N4
• Molecular Weight: 306.41
• Mol File: 509093-76-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Benzimidazol-2-amine, 1-phenyl-5-(1-piperidinylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazol-2-amine, 1-phenyl-5-(1-piperidinylmethyl)-(509093-76-9)
• EPA Substance Registry System: 1H-Benzimidazol-2-amine, 1-phenyl-5-(1-piperidinylmethyl)-(509093-76-9)

Safety Data

• Hazardous Substances Data: 509093-76-9(Hazardous Substances Data)

Upstream product

• 509093-74-7 1-[(4-fluoro-3-nitrophenyl)methyl]piperidine 
• 42564-51-2 4-fluoro-3-nitrobenzaldehyde 
• 453-71-4 3-nitro-4-fluorobenzoic acid 
• 20274-69-5 (4-fluoro-3-nitrophenyl)methanol 
• 509093-75-8 N₁-phenyl-4-piperidin-1-ylmethyl-benzene-1,2-diamine 
• 506-68-3 bromocyane 

Downstream Products

• 509093-77-0 N-(1-Phenyl-5-piperidin-1-ylmethyl-1H-benzoimidazol-2-yl)-3-nitro-benzamide 
• 509093-72-5 N-(1-phenyl-5-piperidin-1-ylmethyl-1H-benzoimidazol-2-yl)-3-trifluoromethylbenzamide 

Relevant articles and documents

Discovery of potent, selective, and orally bioavailable inhibitors of interleukin-1 receptor-associate kinase-4

In this Letter, we report the continued optimization of the N-acyl-2-aminobenzimidazole series, focusing in particular on the N-alkyl substituent and 5-position of the benzimidazole based on the binding mode and the early SAR. These efforts led to the discovery of 16, a highly potent, selective, and orally bioavailable inhibitor of IRAK-4.