51-40-1

Basic information

• Product Name: L-NORADRENALINE BITARTRATE
• Synonyms: (-)-noradrenalineacidtartrate;(-)-noradrenalinebitartratemonohydrate;(-)-noradrenalinetartrate;alpha-(aminomethyl)-3,4-dihydroxy-benzylalcoho(-)-benzylalcohotartrate(1:1);Benzylalcohol,.alpha.-(aminomethyl)-3,4-dihydroxy-,(-)-,tartrate(1:1);Levarterenolbitartrate;l-noradrenalinetartrate;noradrenaline,tartrate(1:1)
• CAS NO: 51-40-1
• Molecular Formula: C₄H₆O₆*C₈H₁₁NO₃
• Molecular Weight: 319.26
• EINECS: 200-095-0
• Product Categories: Standards - 13C & 2H for GC-Mass Spectrometry
• Mol File: 51-40-1.mol
• Article Data: 0

Chemical Properties

• Melting Point: 102-104 °C
• Boiling Point: 442.6 °C at 760 mmHg
• Flash Point: 221.5 °C
• Appearance: /
• Vapor Pressure: 2.24E-21mmHg at 25°C
• PKA: 8.64(at 25℃)
• CAS DataBase Reference: L-NORADRENALINE BITARTRATE(CAS DataBase Reference)
• NIST Chemistry Reference: L-NORADRENALINE BITARTRATE(51-40-1)
• EPA Substance Registry System: L-NORADRENALINE BITARTRATE(51-40-1)

Safety Data

• RIDADR: 3249
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 51-40-1(Hazardous Substances Data)

Usage

Uses

Adrenergic (vasoconstrictor).

Brand name

Levophed (Hospira).

Clinical Use

Hypotension Cardiac arrest (sympathomimetic)

Safety Profile

Poison by intravenous andintraperitoneal routes. When heated to decomposition itemits toxic fumes of NOx.

Drug interactions

Potentially hazardous interactions with other drugs Adrenergic neurone blockers: antagonise hypotensive effect. Anaesthetics: increased risk of arrhythmias with volatile general anaesthetics. Antidepressants: tricyclics may cause hypertension and arrhythmias; MAOIs and moclobemide may cause hypertensive crisis. Beta-blockers: can cause severe hypertension. Clonidine: possibly increased risk of hypertension. Dopaminergics: effects possibly increased by entacapone; avoid with rasagiline. Sympathomimetics: effects possibly enhanced by dopexamine.

Metabolism

Extensively metabolised by catechol-O-methyltransferase (COMT), and monoamine oxidase (MAO). Up to 16% of an intravenous dose is excreted unchanged in the urine with methylated and deaminated metabolites in free and conjugated forms.

InChI:InChI=1/C8H11NO3.C4H6O6/c9-4-8(12)5-1-2-6(10)7(11)3-5;5-1(3(7)8)2(6)4(9)10/h1-3,8,10-12H,4,9H2;1-2,5-6H,(H,7,8)(H,9,10)/t8-;/m1./s1

Synthetic route

4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-undecan-1-al (42028-44-4) + norepinephrine bitartrate (51-40-1) → C30H21F34NO3

Conditions	Yield
With 2-picoline borane complex In isopropyl alcohol at 20℃; for 0.25h;