51307-59-6

Basic information

• Product Name: N-(4-Methoxybenzyl)hydroxylaMine
• Synonyms: N-hydroxy(4-methoxyphenyl)methanamine;N-hydroxy(4-methoxyphenyl)methanamine hydrochloride;N-(4-Methoxybenzyl)hydroxylaMine;N-Hydroxy-1-(4-Methoxyphenyl)MethanaMine;N-(p-Methoxybenzyl)hydroxylamine;N-Hydroxy-4-methoxybenzylamine;N-[(4-methoxyphenyl)methyl]hydroxylamine
• CAS NO: 51307-59-6
• Molecular Formula: C₈H₁₁NO₂
• Molecular Weight: 153.17844
• Mol File: 51307-59-6.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 301.5±44.0 °C(Predicted)
• Appearance: /
• Density: 1.125±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 13.26±0.30(Predicted)
• CAS DataBase Reference: N-(4-Methoxybenzyl)hydroxylaMine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Methoxybenzyl)hydroxylaMine(51307-59-6)
• EPA Substance Registry System: N-(4-Methoxybenzyl)hydroxylaMine(51307-59-6)

Safety Data

• Hazardous Substances Data: 51307-59-6(Hazardous Substances Data)

Usage

General Description

N-(4-Methoxybenzyl)hydroxylamine is a chemical compound that belongs to the class of hydroxylamines, which are organic compounds containing an oxygen atom bonded to a nitrogen atom. It is commonly used as a reagent in organic synthesis, particularly in the preparation of oximes and hydrazones. The presence of a methoxy group in its structure makes it a useful intermediate in the synthesis of pharmaceuticals and agrochemicals. N-(4-Methoxybenzyl)hydroxylamine has also been studied for its potential use in the treatment of neurodegenerative diseases and cancer, due to its ability to scavenge free radicals and inhibit oxidative stress. Despite its beneficial properties, this compound needs to be handled with care, as it can be hazardous if mishandled or inhaled.

InChI:InChI=1S/C8H11NO2/c1-11-8-4-2-7(3-5-8)6-9-10/h2-5,9-10H,6H2,1H3

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 659-28-9 p-trifluoromethoxybenzaldehyde 
• 824-94-2 p-methoxybenzyl chloride 
• 3717-21-3 (E)-4-methoxybenzaldoxime 
• 362663-64-7 [tert-butoxycarbonyl-[(4-methoxyphenyl)methyl]amino] tert-butyl carbonate 
• 3717-21-3 p-methoxyl benzaldoxime 

Downstream Products

• 139189-70-1 (3aR, 6S, 7aR)-6-acetoxymethyl-2-p-methoxybenzyl-4-oxo-tetrahydropyrano<3,4-d>isoxazolidine 
• 105933-69-5 O-trimethylsilyl-N-(p-methoxybenzyl)hydroxylamine 
• 227804-39-9 C₁₃H₁₉NO₂ 
• 267420-54-2 N-(4-methoxybenzyl)-C-(2-furyl)nitrone 
• 823817-59-0 C₁₄H₂₁NO₂ 
• 227804-37-7 C₁₂H₁₇NO₂ 
• 1391090-20-2 N-(4-(tert-butyl)cyclohexylidene)-1-(4-methoxyphenyl)methanamine oxide 
• 1391090-06-4 benzyl (5-(tert-butyl)-2-(2,2,2-trifluoro-N-(4-methoxybenzyl)acetamido)cyclohex-2-en-1-yl)carbamate 
• 1391090-08-6 (Z)-benzyl (2-(2,2,2-trifluoro-N-(4-methoxybenzyl)acetamido) prop-1-en-1-yl)carbamate 
• 1391090-19-9 N-cyclohexylidene-1-(4-methoxyphenyl)methanamine oxide 
• 1391090-05-3 benzyl (2-(2,2,2-trifluoro-N-(4-methoxybenzyl)acetamido)cyclohex-2-en-1-yl)carbamate 
• 1391090-16-6 N-cyclopentylidene-1-(4-methoxyphenyl)methanamine oxide 
• 1391090-02-0 benzyl (2-(2,2,2-trifluoro-N-(4-methoxybenzyl)acetamido) cyclopent-2-en-1-yl)carbamate 
• 1391090-15-5 (Z)-1-(4-methoxyphenyl)-N-(1-phenylpropylidene)methanamine oxide 

Relevant articles and documents

CuH-Catalyzed Regioselective Intramolecular Hydroamination for the Synthesis of Alkyl-Substituted Chiral Aziridines

This report details a general and enantioselective means for the synthesis of alkyl-substituted aziridines. This protocol offers a direct route for the synthesis of alkyl-substituted chiral aziridines from achiral starting materials. Readily accessed ally

One-pot synthesis of dihydrobenzisoxazoles from hydroxylamines, acetylenedicarboxylates, and arynes via in situ generation of nitrones

Aryne [3 + 2] cycloaddition with nitrones generated in situ from the addition of hydroxylamines to acetylenedicarboxylates affords moderate to good yields of dihydrobenzisoxazoles. This reaction extends the current scope of aryne cycloaddition to include in situ generated nitrones and produces functionalized dihydrobenzisoxazoles with a quaternary center.

Cycloaddition of nitrones with arynes generated from benzobisoxadisilole or 2,3-naphthoxadisilole

1,3-Dipolar cycloaddition of nitrones with arynes generated in situ from benzobisoxadisilole or 2,3-naphthoxadisilole afforded the oxadisilole fused benzo[d]isoxazoline or the naphtho[2,3-d]isoxazoline derivatives at room temperature in good yields.