51567-94-3

Basic information

• Product Name: trifluoromethanesulphonic-p-toluenesulphonic acid anhydride
• Synonyms: trifluoromethanesulphonic-p-toluenesulphonic acid anhydride
• CAS NO: 51567-94-3
• Molecular Weight: 304.268
• Mol File: 51567-94-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: trifluoromethanesulphonic-p-toluenesulphonic acid anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: trifluoromethanesulphonic-p-toluenesulphonic acid anhydride(51567-94-3)
• EPA Substance Registry System: trifluoromethanesulphonic-p-toluenesulphonic acid anhydride(51567-94-3)

Safety Data

• Hazardous Substances Data: 51567-94-3(Hazardous Substances Data)

Upstream product

• 2232-08-8 N-tosylimidazole 
• 333-27-7 methyl trifluoromethanesulfonate 
• 98-59-9 p-toluenesulfonyl chloride 
• 1950-69-2 toluene-p-sulfonyl bromide 
• 2923-28-6 silver trifluoromethanesulfonate 

Downstream Products

• 358-23-6 trifluoromethylsulfonic anhydride 
• 4124-41-8 p-toluenesulfonylanhydride 
• 120640-46-2 (2R)-2r-(3,4-dimethoxy-phenyl)-5,7-dimethoxy-3t-(toluene-4-sulfonyloxy)-chroman 
• 120640-48-4 (2R)-2r-(3,4-dimethoxy-phenyl)-5,7-dimethoxy-3c-(toluene-4-sulfonyloxy)-chroman 
• 60520-17-4 toluenesulfonyl [⁽¹⁸⁾F]-fluoride 

Relevant articles and documents

Bioactive Phytochemicals: Efficient Synthesis of Optically Active Substituted Flav-3-enes and Flav-3-en-3-o-R Derivatives

The structural core of flavene (2-phenyl-2H-chromene) is commonly found in plant flavonoids, which exhibit a wide range of biological activities and diverse pharmacological profiles (e.g., antioxidant and anticancer activities). Flavonoids have attracted significant interest in medicinal and synthetic chemistry. Substituted flav-3-ene 13 was exclusively synthesized by the stereoselective elimination of the O-mesyl moiety on C-3 of 5,7,3′,4′-tetramethoxyflavan-3-mesylate 12 with 1,8-diazabicyclo[5.4.0]undec-7-ene. The reaction of 5,7,3′,4′-tetramethoxyflavan-3-one 15 with ytterbium trifluoromethanesulfonate in methanol afforded a novel 3-O-substituted flav-3-ene derivative (3,5,7,3′,4′-pentamethoxyflav-3-ene) 17. The reduction of 4-(1,3,5-trihydroxybenzene)-5,7,3′,4′-tetra-O-benzylflavan-3-one 19b with hydrogen afforded a new compound: 3-hydroxy-4-(1,3,5-trihydroxybenzene)-5,7,3′,4′-tetrahydroxyflavan-3-en-3-ol 21 in good yield (95%), while the acetylation of 19a and 21 afforded the expected novel flav-3-en-3-acetoxy derivatives 20 (92%) and 22 (90%), respectively.