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51704-66-6

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51704-66-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 51704-66-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,7,0 and 4 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 51704-66:
(7*5)+(6*1)+(5*7)+(4*0)+(3*4)+(2*6)+(1*6)=106
106 % 10 = 6
So 51704-66-6 is a valid CAS Registry Number.

51704-66-6Relevant articles and documents

Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic

Pace, Jennifer R.,Deberardinis, Albert M.,Sail, Vibhavari,Tacheva-Grigorova, Silvia K.,Chan, Kelly A.,Tran, Raymond,Raccuia, Daniel S.,Wechsler-Reya, Robert J.,Hadden, M. Kyle

supporting information, p. 3635 - 3649 (2016/05/24)

Itraconazole (ITZ) is an FDA-approved member of the triazole class of antifungal agents. Two recent drug repurposing screens identified ITZ as a promising anticancer chemotherapeutic that inhibits both the angiogenesis and hedgehog (Hh) signaling pathways. We have synthesized and evaluated first- and second-generation ITZ analogues for their anti-Hh and antiangiogenic activities to probe more fully the structural requirements for these anticancer properties. Our overall results suggest that the triazole functionality is required for ITZ-mediated inhibition of angiogenesis but that it is not essential for inhibition of Hh signaling. The synthesis and evaluation of stereochemically defined des-triazole ITZ analogues also provides key information as to the optimal configuration around the dioxolane ring of the ITZ scaffold. Finally, the results from our studies suggest that two distinct cellular mechanisms of action govern the anticancer properties of the ITZ scaffold.

Synthesis and properties of brassinosteroid biosynthesis inhibitor fluorescent probe with dansyl moiety

Hoshi, Tomoki,Yoshizawa, Yuko,Oh, Keimei

, p. 220 - 225 (2016/03/15)

Brassinosteroids (BRs) are important plant hormones that play key roles in plant development and defense responses to environmental cues. To explore the inhibition mechanism of BR biosynthesis, we report the synthesis of novel triazole derivatives with da

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Paragraph 00333; 00336, (2015/01/06)

Described herein are compounds and compositions for the treatment of a fibrotic disease.

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