52265-19-7

Basic information

• Product Name: 1-methyl-4-[(2-nitro-1-phenylethyl)sulfonyl]benzene
• CAS NO: 52265-19-7
• Molecular Formula: C₁₅H₁₅NO₄S
• Molecular Weight: 305.3489
• Mol File: 52265-19-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 514.3°C at 760 mmHg
• Flash Point: 264.8°C
• Density: 1.281g/cm³
• Vapor Pressure: 1.1E-10mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: 1-methyl-4-[(2-nitro-1-phenylethyl)sulfonyl]benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-4-[(2-nitro-1-phenylethyl)sulfonyl]benzene(52265-19-7)
• EPA Substance Registry System: 1-methyl-4-[(2-nitro-1-phenylethyl)sulfonyl]benzene(52265-19-7)

Safety Data

• Hazardous Substances Data: 52265-19-7(Hazardous Substances Data)

Usage

Physical state

White solid

Uses

Reagent in organic synthesis, particularly in the preparation of sulfone-containing compounds

Classification

Nitro-substituted benzene derivative

Functional groups

Sulfonyl group attached to a phenylethyl moiety

Industrial application

Utilized in the pharmaceutical industry for the synthesis of potential drug candidates

Functionality

Ability to introduce sulfonyl functionality into organic molecules

Potential applications

Development of new materials, field of medicinal chemistry.

Upstream product

• 536-57-2 p-toluene sulfinic acid 
• 102-96-5 (2-nitroethenyl)benzene 
• 2028-84-4 p-methylbenzenediazonium chloride 
• 5153-67-3 nitrostyrene 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 536-57-2 p-toluene sulfinic acid 
• 102-96-5 (2-nitroethenyl)benzene 

Relevant articles and documents

Reaction of arendiazonium salts and SO2with α-nitroolefins

In reaction of β-nitrostyrene and 2-(2-nitrovinyl)furan with arenediazonium chlorides and SO2 in the presence of copper(II) chloride products were obtained resulting from addition of arylsulfonyl group and a hydrogen atom across the C=C bond: 2-nitro-1-phenylethylsulfonylarenes and 2-(1-arylsulfonyl-2-nitroethyl)furans respectively. An anion-radical mechanism of the reaction was suggested.

KINETIC STUDIES ON REACTION OF SULFINIC ACIDS WITH CONJUGATED ALKENES: I. KINETICS OF THE ADDITION OF ARENESULFINIC ACIDS TO β-NITROSTYRENE

Addition of unsubstituted and substituted benzenesulfinic acids to β-nitrostyrene has been studied kinetically by means of ultraviolet spectrophotometry.The reaction follows the second-order kinetics: ν=k. .The dependence of rate constants on the temperature and influence of p-substituents on the kinetic parameters have been investigated.The activating energy and the enthalpy of activation are calculated in the temperature range 288-308 K. Key words: Sulfinic acids; β-nitrostyrene; reaction order; rate constants; activating energy; enthalpy of activation.