524712-05-8

Basic information

• Product Name: 3-amino-2-(2-bromophenyl)indole
• Synonyms: 3-amino-2-(2-bromophenyl)indole
• CAS NO: 524712-05-8
• Molecular Weight: 287.159
• Mol File: 524712-05-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-amino-2-(2-bromophenyl)indole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-2-(2-bromophenyl)indole(524712-05-8)
• EPA Substance Registry System: 3-amino-2-(2-bromophenyl)indole(524712-05-8)

Safety Data

• Hazardous Substances Data: 524712-05-8(Hazardous Substances Data)

Upstream product

• 59-88-1 phenylhydrazine hydrochloride 
• 6630-33-7 ortho-bromobenzaldehyde 
• 1885-29-6 anthranilic acid nitrile 
• 2142-69-0 2-bromophenyl methyl ketone 
• 88207-45-8 2-(2'-bromophenyl)-1H-indole 
• 524712-04-7 2-(2-bromophenyl)-3-nitrosoindole 

Downstream Products

• 524712-29-6 tert-butyl 2-{2-[acetyl(2,4-dimethoxybenzyl)amino]ethyl}-2-(2-bromophenyl)-3-oxoindoline-1-carboxylate 
• 524712-31-0 tert-butyl 5a-(2-bromophenyl)-3-(2,4-dimethoxybenzyl)-2-oxo-3,4,5,5a-tetrahydroazepino[4,5-b]indole-6(2H)-carboxylate 
• 524712-28-5 tert-butyl 2-(2-bromophenyl)-2-{2-[(2,4-dimethoxybenzyl)amino]ethyl}-3-oxo-2,3-dihydro-1H-indole-1-carboxylate 
• 524712-16-1 tert-butyl 2-(2-bromophenyl)-3-oxo-2-{3-[(trimethylsilyl)oxy]but-3-enyl}indoline-1-carboxylate 
• 524712-09-2 tert-butyl 2-[2-(benzylamino)ethyl]-2-(2-bromophenyl)-3-oxoindoline-1-carboxylate 
• 524712-25-2 tert-butyl 2-[2-(acetylamino)ethyl]-2-(2-bromophenyl)-3-oxoindoline-1-carboxylate 
• 524712-22-9 tert-butyl 2-(2-bromophenyl)-2-{2-[(methylsulfonyl)oxy]ethyl}-3-oxoindoline-1-carboxylate 
• 524712-14-9 tert-butyl 2-(2-bromophenyl)-3-oxo-2-(3-oxobutyl)indoline-1-carboxylate 
• 524712-17-2 tert-butyl 9a-(2-bromophenyl)-3-oxo-1,2,3,9a-tetrahydro-9H-carbazole-9-carboxylate 
• 524712-24-1 tert-butyl 2-(2-aminoethyl)-2-(2-bromophenyl)-3-oxoindoline-1-carboxylate 
• 524712-23-0 tert-butyl 2-(2-azidoethyl)-2-(2-bromophenyl)-3-oxoindoline-1-carboxylate 

Relevant articles and documents

Development, Scope, and Applications of Titanium(III)-Catalyzed Cyclizations to Aminated N-Heterocycles

The exceptionally mild conditions of a titanium(III)-catalyzed cyclization reaction paired with a convenient acid/base extraction have enabled the straightforward synthesis, isolation, and direct N-functionalization of amino heterocycles such as 3-aminoindoles and -pyrroles. The unprotected heterocycles are ideal building blocks for the installation of aminated indoles and pyrroles into target molecules, but their sensitivity has previously impeded their synthesis by modern catalytic methods. This full paper presents the development and extended scope of the new cyclization methodology. The transformation of the products into fused bis-indoles is also demonstrated along with the discovery of an unusual palladium-catalyzed reductive biphenyl coupling reaction. The titanium(III)-catalyzed cyclization has also been applied to the synthesis of substituted 3-iminoindolines, which are of potential interest for applications in natural product synthesis and exhibit tunable blue-to-green fluorescence properties.

Synthesis of 8-desbromohinckdentine A

Hinckdentine A is an alkaloid isolated from the bryozoan Hincksinoflustra denticulate. This natural product contains a novel and unique 11b, 12, 13, 14, 15, 16-hexahydroazepino[4′,5′:2,3]indolo[1,2-c]quinazoline ring system that has not previously been sy