88207-45-8

Basic information

• Product Name: 2-(2-BROMOPHENYL)-1H-INDOLE
• Synonyms: 1H-INDOLE, 2-(2-BROMOPHENYL)-;2-(2-BROMOPHENYL)-1H-INDOLE
• CAS NO: 88207-45-8
• Molecular Formula: C₁₄H₁₀BrN
• Molecular Weight: 272.144
• Mol File: 88207-45-8.mol
• Article Data: 21

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-BROMOPHENYL)-1H-INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-BROMOPHENYL)-1H-INDOLE(88207-45-8)
• EPA Substance Registry System: 2-(2-BROMOPHENYL)-1H-INDOLE(88207-45-8)

Safety Data

• Hazardous Substances Data: 88207-45-8(Hazardous Substances Data)

Usage

General Description

2-(2-Bromophenyl)-1H-indole is a chemical compound belonging to the indole class, which is commonly found in various natural products and pharmaceuticals. It is derived from indole, a bicyclic heterocyclic organic compound, and is characterized by the presence of a bromine atom and a phenyl group attached to the indole ring. 2-(2-BROMOPHENYL)-1H-INDOLE has been studied for its potential pharmacological activities, including its role as a building block for the synthesis of other biologically active molecules. It has also been investigated for its potential use in drug development and as a precursor in organic synthesis. Additionally, 2-(2-Bromophenyl)-1H-indole has been the subject of interest in the field of medicinal chemistry for its potential applications in the treatment of various diseases.

Upstream product

• 1011736-72-3 N-[1-(2-Bromo-phenyl)-eth-(Z)-ylidene]-N'-phenyl-hydrazine 
• 2142-69-0 2-bromophenyl methyl ketone 
• 59-88-1 phenylhydrazine hydrochloride 
• 100-63-0 phenylhydrazine 
• 201230-82-2 carbon monoxide 
• 1613221-17-2 C₁₉H₁₈BrNO₂ 
• 615-43-0 2-iodophenylamine 
• 103529-16-4 2-[(trimethylsilyl)ethynyl]aniline 
• 52670-38-9 2-ethynylaniline 
• 1213786-20-9 2-[(2-bromophenyl)ethynyl]aniline 
• 62-53-3 aniline 
• 7154-66-7 2-bromobenzoic acid chloride 
• 120-72-9 indole 
• 244205-40-1 (2-bromophenyl)boronic acid 

Downstream Products

• 88207-46-9 2-(2-bromophenyl)-1-phenylsulphonylindole 
• 88207-47-0 2-(2-bromophenyl)-3-chloro-1-phenylsulphonylindole 
• 524712-04-7 2-(2-bromophenyl)-3-nitrosoindole 
• 325765-87-5 2-(2-bromophenyl)-3H-indol-3-one 
• 524712-06-9 2-(2-bromophenyl)-3-imino-indole 
• 524712-05-8 3-amino-2-(2-bromophenyl)indole 
• 524712-07-0 2-(2-bromophenyl)-2-hydroxy-1,2-dihydro-3H-indol-3-one 
• 514806-90-7 2-allyl-2-(2-bromophenyl)-1,2-dihydro-3H-indol-3-one 
• 514806-81-6 3-allyl-2-(2-bromophenyl)-3H-indol-3-ol 
• 524712-13-8 2-(2-bromophenyl)-2-(3-oxobutyl)-1,2-dihydro-3H-indol-3-one 
• 524712-12-7 2-(2-bromophenyl)-3-[2-(2-methyl-1,3-dioxolan-2-yl)ethyl]-3H-indol-3-ol 
• 524712-08-1 tert-butyl 2-allyl-2-(2-bromophenyl)-3-oxoindoline-1-carboxylate 
• 524712-21-8 tert-butyl 2-(2-bromophenyl)-2-(2-hydroxyethyl)-3-oxoindoline-1-carboxylate 
• 524712-23-0 tert-butyl 2-(2-azidoethyl)-2-(2-bromophenyl)-3-oxoindoline-1-carboxylate 

Relevant articles and documents

Copper-Catalyzed Enantioselective C-H Arylation between 2-Arylindoles and Hypervalent Iodine Reagents

The copper-catalyzed enantioselective C-H arylation between 2-arylindoles and hypervalent iodine reagents has been successfully developed, which provides a convenient and economical route to the highly atroposelective synthesis of axially chiral indole de

Iminyl-radicals by electrochemical decarboxylation of α-imino-oxy acids: construction of indole-fused polycyclics

Iminyl radicals are reactive intermediates that can be used for the construction of various valuable heterocycles. Herein, the electrochemical decarboxylation of α-imino-oxy acids for the generation of iminyl radicals has been accomplished under exogenous-oxidant- and metal-free conditions through the use ofnBu4NBr as a mediator. The resulting iminyl radicals undergo intramolecular cyclization smoothly with the adjacent (hetero)arenes to afford a series of indole-fused polycyclic compounds.

An iron(iii)-catalyzed dehydrogenative cross-coupling reaction of indoles with benzylamines to prepare 3-aminoindole derivatives

We report a green cascade approach to prepare a variety of 3-aminoindole derivatives in good to excellent yields through an iron(iii)-catalyzed dehydrogenative cross-coupling reaction of 2-arylindoles and primary benzylamines under mild reaction conditions. Mechanistic studies show that a cascade reaction involves a tert-butyl nitrite (TBN)-mediated nitrosation of 2-substituted indoles and a 1,5-hydrogen shift to afford indolenine oximes, sequential iron(iii)-catalyzed condensation and a 1,5-hydrogen shift over four steps in a one-pot reaction. The reaction shows a broad substrate scope of indoles and benzylamines and tolerates a wide range of functional groups. Moreover, the reaction is easily performed at the gram scale without producing waste after the reaction is completed. The 3-aminoindole product is purified by simple extraction, washing, and recrystallization without flash column chromatography. A double imine ligand containing the 3-aminoindole unit is facile to obtain in a 52% yield in one step. The present method highlights readily available starting materials, a simple purification procedure, and the usage of cheap, nontoxic, and environmentally benign iron(iii) catalysts. This journal is