52644-01-6Relevant articles and documents
Synthesis of (-)-morphine
Taber, Douglass F.,Neubert, Timothy D.,Rheingold, Arnold L.
, p. 12416 - 12417 (2007/10/03)
The preparation of the diastereomerically pure β-tetralone ketal 4 is reported. Intramolecular alkylidene C-H insertion followed by hydrolysis of 4 proceeded to give the enantiomerically pure cyclopentene 15. The key step in this synthesis was the bis-intramolecular cyclization of keto aldehyde 2 to give the tetracyclic intermediate 20. Enone 20 was converted over several steps to (-)-morphine 1. Copyright
Synthesis and pharmacological evaluation of 5,6,7,8-tetrahydro-6-amino>-1,2-naphthalenediol: a novel non-selective dopamine-receptor agonist
Copinga, Swier,Dijkstra, Durk,Vries, Jan B. de,Grol, Cor J.,Horn, Alan S.
, p. 137 - 142 (2007/10/02)
Based on the hypothesis that simultaneous stimulation of dopamine-D1 and -D2 receptors could be beneficial for the treatment of Parkinson's disease, we prepared 5,6,7,8-tetrahydro-6-amino>-1,2-naphthalenedi
Emetic tetralones and the use thereof for inducing regurgitation
-
, (2008/06/13)
5,6-Dialkoxy-2-tetralones (I) are disclosed as useful intermediates in the synthesis of 2-amino-5,6-dialkoxytetralins (III) and 2-amino-5,6-dihydroxytetralins (IV). Compounds of the groups III and IV are potent emetics.