53347-50-5Relevant articles and documents
Cobalt-Catalyzed Carbocyclization of o-Iodobenzaldehydes and o-Iodophenylketones with Alkynes
Chang, Kuo-Jui,Rayabarapu, Dinesh Kumar,Cheng, Chien-Hong
, p. 3963 - 3966 (2003)
(Equation Presented) Treatment of various o-iodobenzaldehydes and o-iodophenyl ketones with alkynes in the presence of Co(dppe)l2 and Zn powder in acetonitrile at 80°C afforded the corresponding indenols in moderate to excellent yields with exceedingly high regioselectivity. For most unsymmetrical alkynes tested, the carbocyclization gave a single regioisomer.
Cobalt-catalyzed regioselective [3+2] annulation of ortho-formyl and acetyl substituted phenylboronic acids with alkynes
Ueda, Mitsuhiro,Ueno, Tamami,Suyama, Yuki,Ryu, Ilhyong
supporting information, p. 2972 - 2974 (2017/07/11)
Treatment of alkynes with ortho-formyl and acetyl phenylboronic acids in the presence of a cobalt catalyst resulted in the formation of 2,3-disubstituted indenols in good yields. When aryl silyl alkynes were used, 2-aryl-3-silyl indenols were obtained reg
Palladium(O)-catalyzed regioselective and multicomponent synthesis of 1,2,3-trisubstituted 1H-indenes
Tsukamoto, Hirokazu,Ueno, Tatsuhiko,Kondo, Yoshinori
, p. 3033 - 3036 (2008/02/09)
A multicomponent synthesis of biologically important indenes bearing three substituent groups at the 1-, 2-, and 3-positions from available o-ethynylbenzaldehyde derivatives and organoboron reagents under pailadium(O) catalysis is described. A two-component coupling reaction in methanol provides 1H-indenols, whereas a three-component reaction involving secondary aliphatic amines as the third component in DMF affords 1H-indenamines. This method allows combinatorial preparation of unsymmetrically substituted 1H-indenes that cannot be prepared via previous synthetic routes.
