53359-69-6

Basic information

• Product Name: 2-Amino-3-nitro-5-trifluoromethylpyridine
• Synonyms: 2-Amino-3-nitro-5-trifluoromethylpyridine;3-Nitro-5-trifluoromethylpyridin-2-ylamine;5-(Trifluoromethyl)-3-nitro-2-aminopyridine;3-Nitro-5-(trifluoroMethyl)pyridin-2-aMine;5-(TRIFLUOROMETHYL)-3-NITROPYRIDIN-2-AMINE
• CAS NO: 53359-69-6
• Molecular Formula: C6H4F3N3O2
• Molecular Weight: 207.11
• Product Categories: amine | nitro-compound
• Mol File: 53359-69-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 274℃
• Flash Point: 119℃
• Appearance: /
• Density: 1.589
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.528
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Amino-3-nitro-5-trifluoromethylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-nitro-5-trifluoromethylpyridine(53359-69-6)
• EPA Substance Registry System: 2-Amino-3-nitro-5-trifluoromethylpyridine(53359-69-6)

Safety Data

• Hazardous Substances Data: 53359-69-6(Hazardous Substances Data)

Usage

General Description

2-Amino-3-nitro-5-trifluoromethylpyridine is a chemical compound with the molecular formula C6H4F3N3O2. It is a yellow crystalline solid that is primarily used as a building block in the synthesis of pharmaceuticals and agrochemicals. 2-Amino-3-nitro-5-trifluoromethylpyridine has a nitro group and an amino group, making it a versatile intermediate for the synthesis of various organic compounds. It is also used in the production of fluorescent dyes and pigments. The trifluoromethyl group in the molecule enhances its stability and reactivity, making it a valuable tool in organic chemistry and drug development. However, it should be handled with caution due to its potential to cause irritation and toxicity if not used appropriately.

InChI:InChI=1/C6H4F3N3O2/c7-6(8,9)3-1-4(12(13)14)5(10)11-2-3/h1-2H,(H2,10,11)

Upstream product

• 74784-70-6 2-amino-5-trifluoromethylpyridine 

Downstream Products

• 33252-64-1 3-nitro-5-trifluoromethylpyridin-2-ol 
• 107867-51-6 5-(trifluoromethyl)-2,3-pyridinediamine 
• 168123-87-3 7-trifluoromethyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione 

Relevant articles and documents

New tetracyclic 1,4-oxazepines constructed via practically simple tandem condensation strategy from readily available synthons

A streamlined synthetic methodology towards novel tetracyclic 1,4-oxazepines from readily available precursors is described. The compounds, designed as more soluble version of the earlier described, poorly soluble dibenzo[b,f][1,4]oxazepines, were obtained in high yields and as a single regioisomer as a result of three tandem chemical events - nucleophilic aromatic substitution, Smiles rearrangement and denitrocyclization.

PYRROLO [2, 3-C] PYRIDINE DERIVATIVES AS P38 KINASE INHIBITING AGENTS

Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (A) are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of asthma, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.

BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS VANILLOID RECEPTOR LIGANDS

Compounds of formula (I) are useful in the treatment of vanilloid-receptor-meditated diseases, such as inflammatory or neuropathic pain and diseases involving sensory nerve function such as asthma, rheumatoid arthritis, osteoarthritis, inflammatory bowel disorders, urinary incontinence, migraine and psoriasis.