74784-70-6

Basic information

• Product Name: 5-(Trifluoromethyl)pyridin-2-amine
• Synonyms: 2-Amino-5-(trifluoromethyl)pyridine 95%;2-Amino-5-(trifluoromethyl)pyridine95%;2-pyridinamine,5-(triflluoromethyl;2-Amine-5-Trifluromethyl Pyridine;5-(Trifluoromethyl)pyridin-2-amine ,97%;5-(trifluoromethyl)pyridine-2-amine;2-Amino-5-Trifluoromethyl Pyridine ,98%;2-Amino-5-(trifluoromethy...
• CAS NO: 74784-70-6
• Molecular Formula: C₆H₅F₃N₂
• Molecular Weight: 162.11
• EINECS: -0
• Product Categories: Amines and Anilines;Heterocycles;Pyridines, Pyrimidines, Purines and Pteredines;pharmacetical;Amines;Pyridines;Pyridine;C6;Heterocyclic Building Blocks;Fluorine series;amine
• Mol File: 74784-70-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 45 °C
• Boiling Point: 90-92/20mbar
• Flash Point: 104 °C
• Appearance: /
• Density: 1,71g/cm
• Vapor Pressure: 0.217mmHg at 25°C
• Refractive Index: 1,533
• Storage Temp.: Room temperature.
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 4.55±0.13(Predicted)
• BRN: 4800784
• CAS DataBase Reference: 5-(Trifluoromethyl)pyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(Trifluoromethyl)pyridin-2-amine(74784-70-6)
• EPA Substance Registry System: 5-(Trifluoromethyl)pyridin-2-amine(74784-70-6)

Safety Data

• Hazard Codes: Xn,Xi,T
• Statements: 20/21/22-36/37/38-25
• Safety Statements: 26-36/37/39-45-36
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 74784-70-6(Hazardous Substances Data)

Usage

Chemical Properties

White to brown solid

Uses

2-?Amino-?5-?(trifluoromethyl)? is a reagent used in the synthesis of selective inhibitors of urokinase plasminogen activator in a non-cytotoxic form of cancer therapy.

InChI:InChI=1/C6H5F3N2/c7-6(8,9)4-1-2-5(10)11-3-4/h1-3H,(H2,10,11)

Upstream product

• 573676-20-7 (5-trifluoromethylpyridin-2-yl)-[7-(3-trifluoromethylpyridin-2-yl)quinazolin-4-yl]amine 
• 69045-78-9 2-chloro-5-(Trichloromethyl)-pyridine 

Downstream Products

• 79456-26-1 2-amino-3-chloro-5-(trifluoromethyl)pyridine 
• 79456-30-7 3-bromo-5-trifluoromethyl-pyridin-2-ylamine 
• 95651-19-7 (5-Trifluoromethyl-pyridin-2-yl)-carbamic acid phenyl ester 
• 300354-14-7 3-cyclopentyl-2(R)-(3,4-dichloro-phenyl)-N-(5-trifluoromethyl-pyridin-2-yl)-propionamide 
• 432050-21-0 C₁₈H₁₃F₃N₄OS 
• 1124213-32-6 N-tert-butyl-3-((4-(3-fluoro-4-(3-(5-(trifluoromethyl)pyridin-2-yl)ureido)benzoyl)piperazin-1-yl)methyl)benzamide 
• 1000845-16-8 phenyl[6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]methanone hydrobromide 
• 1391712-51-8 2-(5-(3,4-dimethoxy-5-nitrophenyl)-1H-imidazol-1-yl)-5-(trifluoromethyl)pyridine 
• 1276680-59-1 6-(trifluoromethyl)-3-(3-(3-(trifluoromethyl)phenylsulfonyl)cyclobutyl)imidazo[1,2-a]pyridine 
• 33252-64-1 3-nitro-5-trifluoromethylpyridin-2-ol 
• 1142192-57-1 3-iodo-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 
• 53359-69-6 5-(Trifluoromethyl)-3-nitro-2-aminopyridine 
• 860457-99-4 ethyl 6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate 

Relevant articles and documents

PROCESS FOR THE CATALYTIC DIRECTED CLEAVAGE OF AMIDE-CONTAINING COMPOUNDS

The present invention relates to a catalytic method for the conversion of amide-containing compouds by means of a build-in directing group and upon the action of a heteronucleophilic compound (in se an amine (RNH2 or RNHR') or an alcohol (ROH) or a thiol (RSH)) in the presence of a metal catalyst to respectively esters, thioesters, carbonates, thiocarbonates and to what is defined as amide-containing compounds (such as carboxamides, urea, carbamates, thiocarbamates). The present invention also relates to these amide-containing compounds having a build-in directing group (DG), as well as the use of such directing groups in the catalytic directed cleavage of N-DG amides with the use of heteronucleophiles (in se an amine (RNH2 or RNHR') or an alcohol (ROH) or thiol (RSH)).

SOME NEW 2-SUBSTITUTED 5-TRIFLUOROMETHYLPYRIDINES

The preparation of the derivatives of 2-amino-, hydrazino-, hydroxy-, and mercapto-5-trifluoromethylpyridines via 2-chloro precursors is describes.Experimental and spectral data of the products together with those of the precursors are presented.