53631-70-2Relevant articles and documents
Simple preparation process of syn phenylpropanolamines from racemic O-TBDPS cyanohydrins
Li, Qing-Lan,Tang, Shi,Zhou, Dong,Tang, Xin-Mei
supporting information, p. 1600 - 1607 (2014/06/09)
In this article, a practically interesting route for the diastereoselective synthesis of phenylpropanolamines has been demonstrated for the first time. Using racemic O-tert-butyldiphenylsilyl (TBDPS) cyanohydrins as the starting materials, various syn phenylpropanolamines and derivatives (e.g., norpseudophedrine) have been successfully prepared in exellent diastereoselectivity via a practically interesting process.