53871-06-0Relevant articles and documents
Effect of lipophilicity modulation on inhibition of human rhinovirus capsid binders
Morley, Andrew,Tomkinson, Nicholas,Cook, Andrew,MacDonald, Catherine,Weaver, Richard,King, Sarah,Jenkinson, Lesley,Unitt, John,McCrae, Christopher,Phillips, Tim
, p. 6031 - 6035 (2011/11/06)
To try and generate broad spectrum human rhinovirus VP1 inhibitors with more attractive physicochemical, DMPK and safety profiles, we explored the current SAR of known VP1 compounds. This lead to the identification of specific structural regions where reduction in polarity can be achieved, so guiding chemistry to analogues with significantly superior profiles to previously reported inhibitors.
NOVEL PYRIDINE DERIVATIVE AND PYRIMIDINE DERIVATIVE (3)
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, (2008/06/13)
A compound represented by the following formula, a salt thereof or a hydrate of the foregoing has an excellent hepatocyte growth factor receptor (HGFR) inhibitory activity, and exhibits anti-tumor activity, angiogenesis inhibitory activity and cancer metastasis inhibitory activity. [R1 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; R2 and R3 represent hydrogen; R4, R5, R6, and R7 may be the same or different and each represents hydrogen, halogen, C1-6 alkyl or the like; R8 represents hydrogen or the like; R9 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; n represents an integer of 1 or 2; X represents -CH=, nitrogen or the like.]
Novel aminoglycoside derivatives
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, (2008/06/13)
Novel aminoglycoside derivatives and their salts containing 2-deoxystreptamine moiety, of which the 1-amino group is acylated by a group represented by the formula: STR1 (wherein R is 4 to 6 membered heterocyclic group containing 1 to 2 nitrogen atoms whi
